Anti-GFR alpha-3 Antibody

Cat: 10213-R118
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Anti-GFR alpha-3 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-GFR alpha-3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human GFR alpha-3
No cross-reactivity in ELISA with Rat GFRA1 Human GFRa2
Immunogen
Recombinant Human GFRA3 protein (Catalog#10213-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA3 (rh GFRA3; Catalog#10213-H08H; NP_001487.2; Met 1-Trp 382).
Source
Monoclonal Rabbit IgG Clone #118
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-GFR alpha-3 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-GFR alpha-3 Antibody Alternative Names
Anti-GDNFR3 Antibody
GFR alpha-3 Background Information

Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons.

Full Name
GDNF family receptor alpha 3
References
  • Widenfalk J, et al. (2000) Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. Cell Tissue Res. 299(3): 409-15.
  • Li J, et al. (2009) Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice. FEBS Lett. 583(15): 2479-85.
  • Yang C, et al. (2006) Distribution of GDNF family receptor alpha3 and RET in rat and human non-neural tissues. J Mol Histol. 37(1-2): 69-77.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-GFR alpha-3 Antibody Rabbit Polyclonal ELISA 50901-T16
    Anti-GFR alpha-3 Antibody Rabbit Polyclonal IHC-P 106718-T08
    Anti-GFR alpha-3 Antibody Rabbit Polyclonal ELISA 10213-RP01
    Anti-GFR alpha-3 Antibody Rabbit Polyclonal ELISA 10213-RP02
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