GFRA1 Protein & Antibody

Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 1

GFRA1 Products

GFRA1 Protein, Recombinant

Molecule	Species	Description	Cat. No
GFRA1	Human	GFRA1 Protein, Recombinant	10330-H08H
GFRA1	Mouse	GFRA1 Protein, Recombinant	50171-M08H
GFRA1	Rat	GFRA1 Protein, Recombinant	80021-R08H

GFRA1 Antibody

Molecule	Application	Description	Cat. No
Mouse GFRA1	WB, ELISA	GFRA1 Antibody, Rabbit PAb	50171-RP01
Mouse GFRA1	WB, ELISA	GFRA1 Antibody, Rabbit PAb (Antigen Affinity Purified)	50171-RP02
Mouse GFRA1	WB, ELISA	GFRA1 Antibody, Rabbit MAb	50171-R009
Mouse GFRA1	WB, ELISA	GFRA1 Antibody, Rabbit MAb	50171-R013
Rat GFRA1	WB, ELISA	GFRA1 Antibody, Rabbit PAb (Antigen Affinity Purified)	80021-RP02

GFRA1 cDNA Clone

Molecule	Species	Description	Cat. No
GFRA1	Human	Homo sapiens GFRA1 transcript variant 2 cDNA Clone(NM_145793.2)	HG10330-M
GFRA1	Mouse	Mus musculus GFRA1 cDNA Clone	MG50171-M
GFRA1	Rat	Rattus norvegicus GFRA1 cDNA Clone	RG80021-M

GFRA1 Alternative Names

GFRA1, DKFZp313E1012, DKFZp686J0156, FLJ10561, FLJ31546, GDNFR, GDNFRA, GFR-ALPHA-1, MGC23045, RET1L, RETL1, TRNR1 [Homo sapiens]

Gfra1, AU042498 [Mus musculus]

GFRA1 Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>GDNF Family>>GFRA1

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>GDNF Family>>GFRA1

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>GFRA1

GFRA1 Related Products

Protein Products

Molecule	Species	Description
GFRA2	Human	GFRA2 Protein, Recombinant
GFRA2	Mouse	GFRA2 Protein, Recombinant
GFRA3	Human	GFRA3/Fc Protein, Recombinant
GFRA3	Human	GFRA3 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human GFRA3	WB, ELISA	GFRA3 Antibody, Rabbit PAb
Human GFRA3	WB, ELISA	GFRA3 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
GFRA2	Human	Homo sapiens GFRA2 cDNA Clone(NM_001495.4)
GFRA2	Mouse	Mus musculus GFRA2 cDNA Clone
GFRA3	Human	Homo sapiens GFRA3 cDNA Clone(NM_001496.3)

GFRA1 Background

Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 1 (GFRA1) is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA1 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. GDNF, a distantly related member of the transforming growth factor-β (TGF-â) superfamily, and its receptor components: GFRA1, Ret and neural cell adhesion molecule (NCAM) have been recently reported to be expressed in the testis and to be involved in the proliferation regulation of immature Sertoli cells.

GFRA1 Related Studies

1. Jing S, et al. (1997) GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J Biol Chem. 272(52): 33111-7.
2. Jing S, et al. (1996) GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell. 85(7):1113-24.
3. Treanor JJ, et al. (1996) Characterization of a multicomponent receptor for GDNF. Nature. 382(6586): 80-3.