Anti-GFR alpha-1 Antibody

Cat: 80021-RP02
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Anti-GFR alpha-1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-GFR alpha-1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat GFR alpha-1
Immunogen
Recombinant Rat GFRA1 protein (Catalog#80021-R08H)
Preparation
Produced in rabbits immunized with purified, recombinant Rat GFRA1 (rR GFRA1; Catalog#80021-R08H; Q62997-1; Met 1-Leu 445). GFRA1 specific IgG was purified by Rat GFRA1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-GFR alpha-1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

GFR alpha-1 Background Information

Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 1 (GFRA1) is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA1 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. GDNF, a distantly related member of the transforming growth factor-β (TGF-â) superfamily, and its receptor components: GFRA1, Ret and neural cell adhesion molecule (NCAM) have been recently reported to be expressed in the testis and to be involved in the proliferation regulation of immature Sertoli cells.

Full Name
GDNF family receptor alpha 1
References
  • Jing S, et al. (1997) GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J Biol Chem. 272(52): 33111-7.
  • Jing S, et al. (1996) GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell. 85(7):1113-24.
  • Treanor JJ, et al. (1996) Characterization of a multicomponent receptor for GDNF. Nature. 382(6586): 80-3.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-GFR alpha-1 Antibody Rabbit Monoclonal ELISA 80021-R029
    Anti-GFR alpha-1 Antibody Rabbit Polyclonal ELISA 80021-RP01
    Anti-GFR alpha-1 Antibody Rabbit Polyclonal ELISA 80021-T16
    Anti-GFR alpha-1 Antibody Rabbit Polyclonal WB,ELISA 50171-RP02
    Anti-GFR alpha-1 Antibody Rabbit Monoclonal ELISA,IHC-P 50171-R009
    Anti-GFR alpha-1 Antibody Rabbit Polyclonal ELISA 50171-RP01
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