Anti-GFPT1 Antibody

Cat: 11071-RP01
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Anti-GFPT1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-GFPT1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human GFPT1
Immunogen
Recombinant Human GFAT protein (Catalog#11071-HNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Human GFAT (rh GFAT; Catalog#11071-HNAE; AAA58502.1; Gln 332-Glu 699). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-GFPT1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-GFPT1 Antibody Alternative Names
Anti-CMSTA1 Antibody;Anti-GFA Antibody;Anti-GFAT Antibody;Anti-GFAT1 Antibody;Anti-GFAT1m Antibody;Anti-GFPT Antibody;Anti-GFPT1L Antibody;Anti-MSLG Antibody
GFPT1 Background Information

Glutamine:fructose-6-phosphate amidotransferase 1 (GFAT), also known as GFPT1, is a member of the N-terminal nucleophile aminotransferases and the first rate-limiting enzyme for the entry of glucose into the hexosamine biosynthesis pathway (HBP) in mammals. GFAT transfers the amino group from the L-glutamine amide to the D-fructose 6-phosphate, producing glutamic acid and glucosamine 6-phosphate. GFAT exists as a homotetramer in cytoplasm, and is proposed to be most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. The full length of human GFAT contains 1 glutamine amidotransferase type-2 domain which catalyzes amide nitrogen transfer from glutamine to the appropriate substrate, and 2 SIS (Sugar Isomerase) domains found in many phosphosugar isomerases and phosphosugar binding proteins.Two isoforms of gfat have been identified: GFAT1 is predominantly expressed in skeletal muscle, whereas GFAT2 is expressed mainly in the central nervous system.

Full Name
glutamine--fructose-6-phosphate transaminase 1
References
  • McKnight G.L., et al.,(1992), Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase. J. Biol. Chem. 267:25208-25212.
  • Hillier L.W., et al., (2005), Generation and annotation of the DNA sequences of human chromosomes 2 and 4.Nature 434:724-731.
  • Beausoleil S.A., et al.,(2006), A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. 24:1285-1292.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-GFPT1 Antibody Rabbit Polyclonal ELISA 11071-RP02
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