Glial cell line-Derived Neurotrophic Factor (GDNF) Family

Glial cell line-Derived Neurotrophic Factor (GDNF) Family Products

Product Categories / Species	Human	Mouse	Rat
Recombinant Proteins	4	2	1
Antibodies	2	2	-
ORF cDNA Clones	5	4	2

GDNF Family Ligands

• GDNF
• Neurturin

GDNF Family Receptors

• GFRA1
• GFRA3
• NCAM1 / CD56
• GFRA2 

Glial cell line-Derived Neurotrophic Factor (GDNF) Family Background

Glial cell line-derived neurotrophic factor (GDNF) and its three relatives constitute the GDNF family ligands. Other members of the GDNF family are neurturin, artemin and persephin. The GDNF family ligands belong to the TGF-beta superfamily, and share a similar conformation with other members of the TGF-beta superfamily. However, proteins of the GDNF family do not signal through TGF-beta receptors. They signal through a multimolecular protein complex that includes the RET receptor tyrosine kinase and receptors of the GFR-alpha family. NCAM may also act as a GDNF family receptor. These neurotrophic factors are essential for the development of a diverse set of neuronal populations, and have been shown to play a role in a number of biological processes including cell survival, cell differentiation and cell migration.

Glial cell line-Derived Neurotrophic Factor (GDNF) Family Related Studies

1. Wang Y, et al. (2002) Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury. Ann N Y Acad Sci. 962:423-37.
2. Carmillo P, et al. (2005) Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry. 44(7):2545-54.
3. Enomoto H. (2005) Regulation of neural development by glial cell line-derived neurotrophic factor family ligands. Anat Sci Int. 80(1):42-52.
4. Yasuhara T, et al. (2007) Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease. Acta Med Okayama. 61(2):51-6.