GDF-8 / Myostatin / MSTN Protein

Growth Differentiation Factor 8

GDF-8 / Myostatin / MSTN Products

GDF-8 / Myostatin / MSTN Protein, Recombinant

Molecule	Species	Description	Cat. No
GDF-8/Myostatin/MSTN	Mouse	GDF-8/Myostatin/MSTN/Fc Protein, Recombinant	50441-M01H

GDF-8 / Myostatin / MSTN cDNA Clone

Molecule	Species	Description	Cat. No
GDF-8/Myostatin/MSTN	Mouse	Mouse GDF-8/Myostatin/MSTN cDNA Clone / ORF Clone	MG50441-G
GDF-8/Myostatin/MSTN	Rat	Rattus norvegicus GDF-8/Myostatin/MSTN cDNA Clone	RG80032-M

GDF-8 / Myostatin / MSTN Related Areas

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>GDF Family>>GDF-8/Myostatin/MSTN

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>GDF Family>>GDF-8/Myostatin/MSTN

GDF-8 / Myostatin / MSTN Alternative Names

GDF-8, Myostatin, MSTN, GDF8 [Homo sapiens]

GDF-8, Myostatin, Mstn, Gdf8, Cmpt, MGC124261, MGC124262, MGC124263 [Mus musculus]

GDF-8 / Myostatin / MSTN Background

GDF-8 / Myostatin / MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF-8 / Myostatin / MSTN is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Experiments in mice have improved that GDF-8 / Myostatin / MSTN is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking Myostatin encoding gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. GDF-8 / Myostatin / MSTN is also expressed in the early phases of fracture healing, and GDF-8 / Myostatin / MSTN deficiency leads to increased fracture callus size and strength. Together, these data suggest that GDF-8 / Myostatin / MSTN has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that GDF-8/Myostatin/MSTN antagonists and inhibitors are likely to enhance both muscle mass and bone strength.

GDF-8 / Myostatin / MSTN Related Studies

1. Elkasrawy MN, et al. (2010) Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 10(1): 56-63.
2. Kambadur R, et al. (1997) Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res. 7 (9): 910-6.
3. McPherron AC, et al. (1997) Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 387 (6628): 83-90.