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> GDF-15 Protein GDF-15 Protein
Growth Differentiation Factor 15
GDF-15 Products
GDF-15 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| GDF-15 | Human | GDF-15/Fc Protein, Recombinant | 10936-H01H |
GDF-15 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| GDF-15 | Human | GDF-15 cDNA Clone / ORF Clone | HG10936-M |
| GDF-15 | Cynomolgus | GDF15 cDNA Clone / ORF Clone | KG90069-G |
GDF-15 Alternative Names
GDF-15, GDF15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB [Homo sapiens]
Gdf15, MIC-1, NAG-1, SBF [Mus musculus]
GDF-15 Related Areas
Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>GDF Family>>GDF-15
Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>GDF Family>>GDF-15
GDF-15 Related Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| GDF-2/BMP-9 | Human | Homo sapiens GDF-2/BMP-9 cDNA Clone(NM_016204.1) |
| GDF-3 | Human | Homo sapiens GDF-3 cDNA Clone(NM_020634.1) |
| GDF-9 | Human | Homo sapiens GDF-9 cDNA Clone(NM_005260.3) |
| BMP-3b/GDF-10 | Human | Homo sapiens BMP-3b/GDF-10 cDNA Clone(NM_004962.2) |
GDF-15 Background
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
GDF-15 Related Studies
- Ago T, et al. (2006) GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 98 (3): 294-297.
- Hsiao E, et al. (2000) Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol. 20 (10): 3742-51.
- Zimmers T, et al. (2005) Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury. Shock. 23 (6): 543-8.
