GBP-2

GBP-2 belongs to the guanylate-binding protein (GBP) family. GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). As GTPases induced by IFN-gamma (Interferon-inducible GTPase), they are key to the protective immunity against microbial and viral pathogens. GBP-2 is a GTPase that converts GTP to GDP and GMP. It binds GTP, GDP and GMP. GBP-2 hydrolyzes GTP very efficiently. GDP rather than GMP is the major reaction product. GBP-2 is induced by interferons that have antiviral effects and inhibit tumor cell proliferation.

GBP-2 Related Areas

 

GBP-2 Alternative Names

GBP-2, GTP-binding protein 2, guanine nucleotide-binding protein 2, huGBP-2, interferon-induced guanylate-binding protein 2 [Homo sapiens]

GBP-2, GTP-binding protein 2, guanine nucleotide-binding protein 2, guanylate nucleotide binding protein 2, interferon-induced guanylate-binding protein 2, mGBP-2, mGBP2 [Mus musculus]

Summaries for GBP-2

Entrez Gene summary for GBP-2:

Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP. [provided by RefSeq, Jul 2008]

OMIM - description for GBP-2:

Guanylate-binding proteins, such as GBP2, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005).

Wikipedia summary for GBP-2:

Interferon-induced guanylate-binding protein 2 is a protein that in humans is encoded by the GBP2 gene.
Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP.

Human GBP-2 Protein General Information

 

• Protein names: GTP-binding protein 2, Short name=GBP-2
• Sequence length: 591 AA.
• Sequence similarities: GBP-2 belongs to the GBP family.
• Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
• Tissue specificity: By IFNG/IFN-gamma during macrophage activation.

General information above from UniProt

Function for GBP-2 Protein

UniProtKB:

GBP-2 binds GTP, GDP and GMP. GBP-2 hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product.

Genatlas:

• GBP-2 is involved in immune response