- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
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Guanylate binding protein 2, interferon-inducible Protein Datasheet
GBP-2 / GBP2 Protein Price Inquiry ( Available Sizes )
GBP-2 / GBP2 Protein Product Information
A DNA sequence encoding the human GBP2 (AAH73163.1) (Met1-Cys588) was expressed with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
GBP-2 / GBP2 Protein QC Testing
|Purity:||> 90% as determined by SDS-PAGE||SDS-PAGE:
GBP-2 / GBP2 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met|
The recombinant human GBP2 consists of 599 amino acids and predicts a molecular mass of 68.3 KDa. It migrates as an approximately 62 KDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
GBP-2 / GBP2 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
GBP-2 / GBP2 Protein Related Products & Topics
GBP-2 / GBP2 Protein Description
GBP-2 is a member of the guanylate-binding protein (GBP) family. As GTPases induced by IFN-gamma (Interferon-inducible GTPase), GBPS are key to the protective immunity against microbial and viral pathogens. GBPS are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). GBP-2 is a GTPase that converts GTP to GDP and GMP. It binds GTP, GDP and GMP. GBP-2 hydrolyzes GTP very efficiently. GDP rather than GMP is the major reaction product. GBP-2 is induced by interferons that have antiviral effects and inhibit tumor cell proliferation.
- Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.
- Wistow G. et al., 2002, Mol Vis. 8: 205-20.
- Neun R et al., 1996, FEBS Lett. 390 (1): 69-72.