GAPDH Protein

Glyceraldehyde-3-phosphate dehydrogenase

GAPDH Products

GAPDH Protein, Recombinant

Molecule	Species	Description	Cat. No
GAPDH	Human	GAPDH Protein, Recombinant	10094-H07E

GAPDH cDNA Clone

Molecule	Species	Description	Cat. No
GAPDH	Human	GAPDH cDNA Clone / ORF Clone	HG10094-M
GAPDH	Mouse	GAPDH cDNA Clone / ORF Clone	MG50545-M

GAPDH Related Areas

Signal Transduction>>Adaptor Protein>> GAPDH

GAPDH Alternative Names

CDABP0047, G3PD, GAPD, MGC88685 [Homo sapiens]

Gapd, MGC102544, MGC102546, MGC103190, MGC103191, MGC105239 [Mus musculus]

GAPDH Background

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimer's disease. Besides, deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinson's disease, binds to GAPDH and displays neuroprotective actions.

GAPDH Related Studies

1. Hara MR, et al. (2006) Neuroprotection by pharmacologic blockade of the GAPDH death cascade. PNA. 103 (10): 3887-9.
2. Hara MR, et al. (2006) GAPDH as a sensor of NO stress.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1762 (5): 502-9.
3. Tarze A, et al. (2007) GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilizationGAPDH and apoptosis. Oncogene. 26: 2606-20.
4. Yi MK, et al. (2000) Functional Significance of the Interaction of Hepatitis A Virus RNA with Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH): Opposing Effects of GAPDH and Polypyrimidine Tract Binding Protein on Internal Ribosome Entry Site Function. Journal of Virology. 74 (14) : 6459-68.