GAP-43

GAP-43 is associated with nerve growth. GAP-43 is a major component of the motile "growth cones" that form the tips of elongating axons. GAP-43 plays a role in axonal and dendritic filopodia induction.

GAP-43 Related Areas

Neuroscience>>Axon Guidance>>Other Axon Guidance Proteins>>GAP-43

Neuroscience>>Synaptic Protein>>GAP-43

GAP-43 Alternative Names

GAP-43, B-50, PP46, Gap43 [Homo sapiens]

GAP-43, B-50, Basp2, GAP43 [Mus musculus]

Summaries for GAP-43

Entrez Gene summary for GAP43:

The protein encoded by this GAP43 gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. GAP-43 is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Wikipedia summary for GAP-43:

Growth Associated Protein 43 also known as GAP-43 is a protein that in humans is encoded by the GAP43 gene. GAP-43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development, during axonal regeneration and is phosphorylated after long-term potentiation (LTP) and after learning. GAP-43 is considered a crucial component of the axon and presynaptic terminal, its null mutation leading to death within days after birth due to axon pathfinding defects.

Human GAP-43 Protein General Information

 

• Protein names: Growth-associated protein 43
• Sequence length: 238 AA.
• Sequence similarities: GAP-43 belongs to the neuromodulin family. GAP-43 contains 1 IQ domain.
• Post-translational modification: Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
  Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction.
• Subunit structure: GAP-43 is identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. GAP-43 binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence
• Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection › growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction › synapse. Cell projection › filopodium membrane; Peripheral membrane protein. Note: Cytoplasmic surface of growth cone and synaptic plasma membranes.

General information above from UniProt

Function for GAP-43 Protein

UniProtKB:

GAP-43 is associated with nerve growth. GAP-43 is a major component of the motile "growth cones" that form the tips of elongating axons. GAP-43 plays a role in axonal and dendritic filopodia induction.

Genatlas:

• GAP-43 is palmitoylated neuronal protein component of neurons regenerative response
• GAP-43 is implicated in axogenesis in several of the same neuronal types
• GAP-43 is presynaptic protein implicated in axonal growth, neuronal differentiation, plasticity, and regeneration
• GAP-43 is involved in neuronal plasticity and neurotransmitter release
• GAP-43 is involved in axon growth and synaptic plasticity (Pubmed 12221279)
• BASP1 and GAP-43 have overlapping, but not identical, functions in relation to neurite outgrowth (Pubmed 18438920)
• neurotrophin-dependent membrane-bound phosphoprotein highly expressed during the development of the nervous system (Pubmed 19443652)

Homology for human GAP-43

• homolog to murine Basp2