G-CSFR Protein & Antibody (CD114)

Granulocyte Colony Stimulating Factor Receptor (Cluster of Differentiation 114)

G-CSFR Protein & Antibody Products

G-CSFR Protein, Recombinant

Molecule	Species	Description	Cat. No
G-CSFR/CD114	Human	G-CSFR/CD114/Fc Protein, Recombinant	10218-H02H
G-CSFR/CD114	Human	G-CSFR/CD114 Protein, Recombinant	10218-H08H

  10218-H02H:  ED₅₀ = 1-4 ng / ml Measured by its ability to inhibit the GCSF-induced proliferation of NFS-60 mouse myeloid cells.

G-CSFR Antibody

Molecule	Application	Description	Cat. No
Human G-CSFR/CD114	ELISA	Mouse Monoclonal Antibody	10218-MM01

G-CSFR Alternative Names

G-CSFR, CD114, GCSFR, CSF3R [Homo sapiens]

G-CSFR, Cd114, Csf3r, RP23-140F18.1, Csfgr, MGC141472, MGC141473 [Mus musculus]

G-CSFR Related Areas

Cardiovascular>>Platelet>>G-CSFR/CD114

Cancer>>Growth Factor & Receptor>>CSF & Receptor>>G-CSFR/CD114

Immunology>>Cytokine & Receptor>>CSF & Receptor>>G-CSFR/CD114

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family Signaling Related Molecules>>G-CSFR/CD114

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>G-CSFR/CD114

G-CSFR Background

Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.

G-CSFR Related Studies

1. Kasper B, et al. (1999) Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA. Int J Hematol. 70(4): 241-7.
2. Hollenstein U, et al. (2000) Endotoxin down-modulates granulocyte colony-stimulating factor receptor (CD114) on human neutrophils. J Infect Dis. 182(1): 343-6.
3. Kindwall-Keller TL, et al. (2008) Role of the proteasome in modulating native G-CSFR expression. Cytokine. 43(2): 114-23.
4. Beel K, et al. (2009) G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia. Haematologica. 94(10): 1449-52.