Anti-GCSF Receptor Antibody

Cat: 10218-MM01
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All GCSF Receptor Reagents
Anti-GCSF Receptor Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-GCSF Receptor Antibody
Validated applications
Species reactivity
Reacts with: Human
Human GCSF Receptor
Human cell-derived rhG-CSFR extracellular domain (Catalog#10218-HCCH)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human G-CSFR extracellular domain (rhG-CSFR; Catalog #10218-HCCH; aa 1-621; NP_000751.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #2D9G1E3
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-GCSF Receptor Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:2000  
ELISA(Det) 1:1000-1:10000 This antibody will detect Human G-CSF R / CD114 / CSF3R in ELISA pair set (Catalog: # SEK10218). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10218-MM06).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-GCSF Receptor Antibody Alternative Names
Anti-CD114 Antibody;Anti-CSF3R Antibody;Anti-G-CSF R Antibody;Anti-GCSFR Antibody
GCSF Receptor Background Information

Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.

Full Name
colony stimulating factor 3 receptor (granulocyte)
  • Kasper B, et al. (1999) Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA. Int J Hematol. 70(4): 241-7.
  • Hollenstein U, et al. (2000) Endotoxin down-modulates granulocyte colony-stimulating factor receptor (CD114) on human neutrophils. J Infect Dis. 182(1): 343-6.
  • Kindwall-Keller TL, et al. (2008) Role of the proteasome in modulating native G-CSFR expression. Cytokine. 43(2): 114-23.
  • Beel K, et al. (2009) G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia. Haematologica. 94(10): 1449-52.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-GCSF Receptor Antibody Mouse Monoclonal ELISA(Cap),ICC/IF,IF 10218-MM06
    Anti-GCSF Receptor Antibody Mouse Monoclonal ICC/IF,IF 10218-MM03
    Anti-GCSF Receptor Antibody (APC) Mouse Monoclonal FCM 10218-MM06-A
    Anti-GCSF Receptor Antibody (PE) Mouse Monoclonal FCM 10218-MM06-P
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