Frizzled-1 (FZD1)

Frizzled-1 is the receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-1 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Frizzled-1 is activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Frizzled-1 (FZD1) Related Areas

Signal Transduction>>Wnt Signaling Pathway>>Wnt Receptor>>Frizzled-1/FZD1

Stem Cell>>Wnt Signaling Pathway>>Wnt Receptor>>Frizzled-1/FZD1

Frizzled-1 (FZD1) Alternative Names

Frizzled-1, FZD1, DKFZp564G072, FLJ95923 [Homo sapiens]

Frizzled-1, Fzd1, AW227548, FZ-1 [Mus musculus]

Summaries for Frizzled-1 (FZD1)

Entrez Gene summary for FZD1:

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Frizzled-1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

OMIM - description for Frizzled-1:

Members of the 'frizzled' (Fz) gene family (see 606143) encode 7-transmembrane domain proteins that are receptors for Wnt (see 164975) signaling proteins.

Wikipedia summary for Frizzled-1:

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.

Human Frizzled-1 (FZD1) Protein General Information

 

• Protein names: Frizzled-1, Short name=Fz-1
• Sequence length: 647 AA.
• Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway
• Sequence similarities: Frizzled-1 belongs to the G-protein coupled receptor Fz/Smo family. Frizzled-1 contains 1 FZ (frizzled) domain.
• Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
• Tissue specificity: Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.

General information above from UniProt

Function for Frizzled-1 (FZD1) Protein

UniProtKB:

Frizzled-1 is the receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-1 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Frizzled-1 is activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Genatlas:

• Frizzled-1 is a receptors for Wnt signaling proteins
• Frizzled-1 is a functional partner for certain Wnts in inducing TCF dependent transcription (Pubmed 10557084)

Homology for human Frizzled-1 (FZD1)

• ortholog to Fzd1, Mus musculus
• ortholog to Fzd1, Rattus norvegicus
• ortholog to FZD1, Pan troglodytes
• ortholog to fzd1, Danio rerio