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Frizzled-1/FZD1  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
50092-M08H-50
50092-M08H-100
50 µg 
100 µg 
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Frizzled-1/FZD1 Related Area

Frizzled-1/FZD1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

Frizzled-1/FZD1 Summary & Protein Information

Frizzled-1/FZD1 Background

Gene Summary: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Frizzled-1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subunit structure: Interacts with MYOC. {ECO:0000269|PubMed:19188438}.
Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. {ECO:0000250}.; The FZ domain is involved in binding with Wnt ligands. {ECO:0000250}.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue specificity: Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.
Post-translational: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
Sequence similarity: Belongs to the G-protein coupled receptor Fz/Smo family. {ECO:0000305}.; Contains 1 FZ (frizzled) domain. {ECO:0000255|PROSITE-ProRule:PRU00090}.
General information above from UniProt

Frizzled-1, also known as FZD1, belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Frizzled-1/FZD1 Alternative Name

Frizzled-1/FZD1 Related Studies

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