Anti-FZD1 Antibody

Cat: 50092-RP01
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Anti-FZD1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-FZD1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse FZD1
Immunogen
Recombinant Mouse FZD1 protein (Catalog#50092-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse FZD1 / Frizzled-1 extracellular domain (rM FZD1; Catalog#50092-M08H; NP_067432.2; Met 1-His 248). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FZD1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-FZD1 Antibody Alternative Names
Anti-AW227548 Antibody;Anti-FZ-1 Antibody;Anti-Fz1 Antibody
FZD1 Background Information

Frizzled-1, also known as FZD1, belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Full Name
frizzled class receptor 1
References
  • Gazit A., et al.,(1999), Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18:5959-5966.
  • Sagara N., et al., (1998), Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.Biochem. Biophys. Res. Commun. 252:117-122.
  • Scherer S.W., et al.,(2003), Human chromosome 7: DNA sequence and biology.Science 300:767-772.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-FZD1 Antibody Rabbit Monoclonal ELISA 50092-R109
    Anti-FZD1 Antibody Rabbit Polyclonal ELISA 50092-T16
    Anti-FZD1 Antibody Rabbit Polyclonal ELISA,IHC-P 50092-RP02
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