Anti-FHIT Antibody

Cat: 14434-RP01

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Anti-FHIT Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-FHIT Antibody
Validated applications
Species reactivity
Reacts with: Human
Human FHIT
Recombinant Human Fragile histidine triad / FHIT protein (Catalog#14434-H08E)
Produced in rabbits immunized with purified, recombinant Human Fragile histidine triad / FHIT (rh Fragile histidine triad / FHIT; Catalog#14434-H08E; P49789; Met1-Gln147). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FHIT Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-FHIT Antibody Alternative Names
Anti-AP3Aase Antibody;Anti-FRA3B Antibody
FHIT Background Information

Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. It has been shown that fragile histidine triad synergizes with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. Fragile histidine triad gene works as a tumor suppressor as it has been demonstrated in animal studies. The exact molecular function of FHIT is still partially unclear. It also acts as a tumor suppressor of HER2/neu driven breast cancer.

Full Name
fragile histidine triad
  • Lambert N, et al. (2006) An RNA gene expressed during cortical development evolved rapidly in humans. Nature. 443(7108):167-72.
  • Pekarsky Y, et al. (1998) Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci. 95(15):8744-9.
  • Ohta M, et al. (1996) The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell. 84(4): 587-97.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-FHIT Antibody Rabbit Monoclonal WB,ELISA,IHC-P,ICC/IF,IF 14434-R104
    Anti-FHIT Antibody Rabbit Polyclonal ELISA 14434-T16
    Anti-FHIT Antibody Rabbit Polyclonal ELISA,IHC-P,ICC/IF,IF 14434-T26
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