Fractalkine (Protein | Antibody | cDNA Clone | ELISA Kit)

All Fractalkine reagents are produced in house and quality controlled, including 7 Fractalkine Antibody, 2 Fractalkine ELISA, 52 Fractalkine Gene, 6 Fractalkine Lysate, 8 Fractalkine Protein, 3 Fractalkine qPCR. All Fractalkine reagents are ready to use.

Fractalkine Protein (8)

Fractalkine Antibody (7)

Fractalkine ELISA Kit & Match Antibody ELISA Pair Set (2)

Fractalkine cDNA Clone (52)

NM_002996.3
NM_009142.3
NM_134455.1
AB648939.1

Fractalkine Lysate (6)

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Fractalkine Background

Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.

Fractalkine References

  • Imai T, et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 91(4): 521-30.
  • Papadopoulos EJ, et al. (1999) Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol. 29 (8): 2551-9.
  • Umehara H, et al. (2004) Fractalkine in vascular biology: from basic research to clinical disease". Arterioscler. Thromb Vasc Biol. 24 (1): 34-40.