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> Fractalkine / CX3CL1 Protein & Antibody Fractalkine / CX3CL1 Protein & Antibody
Chemokine (C-X3-C motif) Ligand 1
Fractalkine / CX3CL1 Products
Fractalkine / CX3CL1 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Fractalkine /CX3CL1 | Human | Fractalkine / CX3CL1 Protein, Recombinant | 10636-H08H |
Fractalkine / CX3CL1 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human Fractalkine /CX3CL1 | WB, ELISA | Fractalkine / CX3CL1 Mouse MAb | 10636-MM02 |
| Human Fractalkine /CX3CL1 | FCM | Fractalkine / CX3CL1 Antibody | 10636-MM12 |
| Human Fractalkine /CX3CL1 | FCM | Fractalkine / CX3CL1 Antibody ( FITC ) | 10636-MM12-F |
| Human Fractalkine /CX3CL1 | ELISA | Fractalkine / CX3CL1 Rabbit PAb | 10636-RP01 |
| Human Fractalkine /CX3CL1 | WB, ELISA | Fractalkine / CX3CL1 Rabbit PAb (Antigen Affinity Purified) | 10636-RP03 |
| Human Fractalkine /CX3CL1 | WB, ELISA | Fractalkine / CX3CL1 Antibody | 10636-R409 |
Fractalkine / CX3CL1 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Fractalkine /CX3CL1 | Human | Homo sapiens Fractalkine / CX3CL1 cDNA Clone (NM_002996.3) | HG10636-M |
| Fractalkine /CX3CL1 | Mouse | Mouse Fractalkine / CX3CL1 cDNA Clone / ORF Clone | MG50917-G |
| Fractalkine /CX3CL1 | Canine | Canine CX3CL1 Gene cDNA Clone / ORF Clone | DG70071-G |
| Fractalkine /CX3CL1 | Rat | Rat Fractalkine / CX3CL1 cDNA Clone | RG80163-G |
Fractalkine / CX3CL1 Alternative Names
Fractalkine, CX3CL1, CXC3, CXC3C, ABCD-3, SCYD1, C3Xkine, NTN, NTT, neurotactin [Homo sapiens]
Fractalkine, Cx3cl1, Cxc3, CX3C, ABCD-3, Scyd1, AI848747, D8Bwg0439e, AB030188 [Mus musculus]
Fractalkine / CX3CL1 Related Areas
Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>Fractalkine/CX3CL1
Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>Fractalkine/CX3CL1
Fractalkine / CX3CL1 Background
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.
Fractalkine / CX3CL1 Related Studies
- Imai T, et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 91(4): 521-30.
- Papadopoulos EJ, et al. (1999) Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol. 29 (8): 2551-9.
- Umehara H, et al. (2004) Fractalkine in vascular biology: from basic research to clinical disease". Arterioscler. Thromb Vasc Biol. 24 (1): 34-40.
