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Fractalkine/CX3CL1 Protein, Antibody, ELISA Kit, cDNA Clone

Fractalkine/CX3CL1 Related Areas

Fractalkine/CX3CL1 Related Pathways

Fractalkine/CX3CL1 Related Product

Fractalkine/CX3CL1 Summary & Protein Information

Fractalkine/CX3CL1 Related Information

Fractalkine/CX3CL1 Background

Subunit structure: Monomer. Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Processed fractalkine: Secreted.
Tissue specificity: Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.
Induction: By TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells.
Post-translational: A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form (By similarity).
O-glycosylated with core 1 or possibly core 8 glycans.
Sequence similarity: Belongs to the intercrine delta family.
General information above from UniProt

Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.

Fractalkine/CX3CL1 Alternative Name

ABCD-3,C3Xkine,CX3CL1,CXC3,CXC3C,Fractalkine,neurotactin,NTN,NTT,SCYD1, [human]
AB030188,ABCD-3,AI848747,CX3C,Cx3cl1,Cxc3,D8Bwg0439e,Fractalkine,Scyd1, [mouse]

Fractalkine/CX3CL1 Related Studies

  • Imai T, et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 91(4): 521-30.
  • Papadopoulos EJ, et al. (1999) Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol. 29 (8): 2551-9.
  • Umehara H, et al. (2004) Fractalkine in vascular biology: from basic research to clinical disease". Arterioscler. Thromb Vasc Biol. 24 (1): 34-40.