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> Follistatin Protein Follistatin Protein
Follistatin Products
Follistatin Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Follistatin | Human | Follistatin Protein, Recombinant | 10685-H02H |
| Follistatin | Human | Follistatin (FS288) Protein, Recombinant | 13092-H08H |
| Follistatin | Mouse | FST / Follistatin ( FS288 ) Protein, Recombinant | 50035-M02S |
| Follistatin | Mouse | Follistatin / FST Protein, Recombinant | 50035-M08H |
Follistatin cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Follistatin | Human | Human Follistatin/FST cDNA Clone / ORF Clone | HG10685-M |
Follistatin Related Areas
Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>Follistatin
Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>Follistatin
Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Modulators>>Follistatin
Follistatin Alternative Names
Follistatin, FST, FS [Homo sapiens]
Follistatin, Fst [Mus musculus]
Follistatin Background
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin, it is imperative to determine the nature of the activin/follistatin binding complex.
Follistatin Related Studies
- Carroll RS, et al. (1989) Inhibin, activin, and follistatin: regulation of follicle-stimulating hormone messenger ribonucleic acid levels. Mol Endocrinol. 3(12): 1969-76.
- Fainsod A, et al. (1997) The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4. Mech Dev. 63(1): 39-50.
- Kaiser UB, et al. (1992) Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats. Endocrinology. 130(5): 3048-56.
