Flavokinase (RFK)

Flavokinase is a member of the transferases family, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. Flavokinase is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis. It has been proposed that TNF, through the activation of the flavokinase gene, enhances the incorporation of FAD in NADPH oxidase enzymes, which is a critical step for the assembly and activation of NADPH oxidase.

Flavokinase (RFK) Related Areas

 

Flavokinase (RFK) Alternative Names

RP11-422N19.2, RIFK, 0610038L10Rik, ATP:riboflavin 5'-phosphotransferase, flavokinase [Homo sapiens]

0610038L10Rik, AF031381, KOI-4, ATP:riboflavin 5'-phosphotransferase, flavokinase [Mus musculus]

Summaries for Flavokinase (RFK)

OMIM - description for Flavokinase:

Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003).

Human Flavokinase (RFK) Protein General Information

 

• Protein names: Flavokinase
• Sequence length: 155 AA.
• Catalytic activity: ATP + riboflavin = ADP + FMN.
• Cofactor: Zinc or magnesium.
• Pathway: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.
• Subunit structure: Monomer.
• Subcellular location: Cytoplasm
• Tissue specificity: Flavokinase is detected in brain, placenta and urinary bladder.
• Sequence caution: The sequence AAH07069.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA92033.1 differs from that shown. Reason: Erroneous initiation.

General information above from UniProt

Function for Flavokinase (RFK) Protein

UniProtKB:

Flavokinase catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN).

Genatlas:

• riboflavin kinase activity
• Flavokinase catalyzes the phosphorylation of riboflavin (vitamin B2) to form FMN, an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan 2003)