Fibronectin Protein & Antibody (FN1)

Fibronectin Products

Fibronectin Protein, Recombinant

Molecule	Species	Description	Cat. No
Fibronectin/FN1	Human	Fibronectin Fragment 2 Protein, Recombinant	10314-H08H

  10314-H08H: Immobilized mouse APCS at 10 µg/ml (100 µl/well) can bind biotinylated Fibronectin Fragment 2 with a linear ranger of 0.625-5 µg/ml. Measured by its binding ability in a functional ELISA.

Fibronectin Antibody

Molecule	Application	Description	Cat. No
Human Fibronectin/FN1	WB, ELISA	Mouse Monoclonal Antibody	10314-MM02
Human Fibronectin/FN1	WB, ELISA	Fibronectin/FN1 Antibody, Rabbit MAb	10314-R014
Human Fibronectin/FN1	ELISA	Rabbit Polyclonal Antibody	10314-RP01
Human Fibronectin/FN1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10314-RP03

Fibronectin Related Areas

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Osteoblast & Osteoclast Marker>>Fibronectin/FN1

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>Fibronectin/FN1

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>Fibronectin/FN1

Immunology>>Innate Immunity>>Coagulation>>Fibronectin/FN1

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>Fibronectin/FN1

Cardiovascular>>Coagulation>>Fibronectin/FN1

Fibronectin Alternative Names

Fibronectin 1, FN, CIG, DKFZp686F10164, DKFZp686H0342, DKFZp686I1370, DKFZp686O13149, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF [Homo sapiens]

Fibronectin 1, Fn1, E330027I09, Fn, Fn-1, MGC117493 [Mus musculus]

Fibronectin Background

Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet thrombus formation and diseases associated with thrombosis including vascular remodeling, atherosclerosis, and cardiac repair following a myocardial infarct. Each monomer of FN consists of three types of homologous repeating units, that is 12 type I repeats, two type II repeats and 15-17 type III repeats. The occurrence of multiple isoforms results from alternative mRNA splicing of the ED-A, ED-B and III-CS regions, and subsequent post-translational modification. As an ECM component and one of the primary cell adhesion molecules, Fibronectin can be a ligand for fibrin, heparin, chondroitin sulfate, collagen/gelatin, as well as many integrin receptors through which FN mediates the variety of cellular signaling pathways. The study of solid human tumors showed among the early signs of malignant transformation the fragmentation of pericellular FN, concommitent with the increase of its production by the peritumoral stroma. These results should encourage further investigations concerning the potential importance of Fn production and breakdown during cancer progression. FN1 expression has been described to increase significantly from the morula towards the early blastocyst stage, suggesting that FN1 may also be involved in early blastocyst formation. The fragment 2 of FN comprises the first 7 FN type III repeats and is suggested to be important for self association during fibril growth via the key module III2.

Fibronectin Related Studies

1. Labat-Robert J. (2002) Fibronectin in malignancy. Semin Cancer Biol. 12(3): 187-95.
2. Goossens K, et al. (2009) Quantification of fibronectin 1 (FN1) splice variants, including two novel ones, and analysis of integrins as candidate FN1 receptors in bovine preimplantation embryos. BMC Dev Biol. 9: 1.
3. Maurer LM, et al. (2010) Emerging roles of fibronectin in thrombosis. Thromb Res. 125(4): 287-91.