Fetuin-A Protein & Antibody (AHSG)

Alpha-2-HS-Glycoprotein

Fetuin-A Products

Fetuin-A Protein, Recombinant

Molecule	Species	Description	Cat. No
Fetuin-A/AHSG	Human	Fetuin-A/AHSG Protein, Recombinant	10318-H08H
Fetuin-A/AHSG	Mouse	Fetuin-A/AHSG Protein, Recombinant	50093-M08H

  10318-H08H:  Immobilized human FCN1 at 10 µg/mL can bind biotinylated recombinant human Fetuin-A with a linear range of 16-2000 ng/ml. Measured by its binding ability in a functional ELISA.

  50093-M08H:  Immobilized human FCN1 at 10 µg/mL can bind biotinylated recombinant mouse Fetuin-A with a linear range of 16-2000 ng/ml. Measured by its binding ability in a functional ELISA.

Fetuin-A Antibody

Molecule	Application	Description	Cat. No
Human Fetuin-A/AHSG	WB, ELISA	Mouse Monoclonal Antibody	10318-MM02
Human Fetuin-A/AHSG	WB, ELISA	Rabbit Monoclonal Antibody	10318-R001
Human Fetuin-A/AHSG	ELISA	Rabbit Polyclonal Antibody	10318-RP01
Human Fetuin-A/AHSG	WB	Rabbit Polyclonal Antibody	10318-RP03
Mouse Fetuin-A/AHSG	WB, ELISA	Fetuin-A/AHSG Antibody, Rabbit MAb	50093-R002

Fetuin-A ELISA Kit

Molecule	Application	Description	Cat. No
Human Fetuin-A/AHSG	ELISA	Fetuin-A/AHSG ELISA Kit	SEK10318
Human Fetuin-A/AHSG	ELISA	Fetuin-A/AHSG ELISA Kit	SEKA10318

Fetuin-A cDNA Clone

Molecule	Species	Description	Cat. No
Fetuin-A/AHSG	Human	Homo sapiens Fetuin-A/AHSG cDNA Clone(NM_001622.2)	HG10318-M
Fetuin-A/AHSG	Mouse	Mus musculus Fetuin-A/AHSG cDNA Clone	MG50093-M

Fetuin-A Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Fetuin-A/AHSG

Fetuin-A Alternative Names

Fetuin-A, AHSG, A2HS, AHS, FETUA, HSGA [Homo sapiens]

Fetuin-A, Ahsg [Mus musculus] [Mus musculus]

Fetuin-A Background

Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.

Fetuin-A Related Studies

1. Mehrotra R. (2007) Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int. 72(2): 137-40.
2. Westenfeld R, et al. (2007) Vascular calcification and fetuin-A deficiency in chronic kidney disease. Trends Cardiovasc Med. 17(4): 124-8.
3. Heiss A, et al. (2008). Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J Biol Chem. 283 (21): 14815–25.
4. Jahnen-Dechent W, et al. (2008). Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification. J Mol Med. 86 (4): 379–89.
5. Hedrich J, et al. (2010) Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. Biochemistry. 49(39): 8599-607.