Anti-Fetuin A Antibody

Cat: 10318-MM02
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Anti-Fetuin A Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Fetuin A Antibody
Validated applications
Species reactivity
Reacts with: Human
Human Fetuin A
Human cell-derived Fetuin-A protein (Catalog#10318-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Fetuin-A / AHSG (rhFetuin-A; Catalog#10318-H08H; NP_001613.2; Met 1-Val 367). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #6C8E9A10
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Fetuin A Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
ELISA(Cap) 1:250-1:2000 This antibody will detect Human Fetuin-A in ELISA pair set (Catalog: # SEKA10318). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10318-R001).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Fetuin A Antibody Alternative Names
Anti-A2HS Antibody;Anti-AHS Antibody;Anti-FETUA Antibody;Anti-HSGA Antibody
Fetuin A Background Information

Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.

Full Name
  • Mehrotra R. (2007) Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int. 72(2): 137-40.
  • Westenfeld R, et al. (2007) Vascular calcification and fetuin-A deficiency in chronic kidney disease. Trends Cardiovasc Med. 17(4): 124-8.
  • Heiss A, et al. (2008). Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J Biol Chem. 283 (21): 14815-25.
  • Jahnen-Dechent W, et al. (2008). Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification. J Mol Med. 86 (4): 379-89.
  • Hedrich J, et al. (2010) Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. Biochemistry. 49(39): 8599-607.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Fetuin A Antibody Rabbit Monoclonal IHC-P 50093-R022
    Anti-Fetuin A Antibody Rabbit Polyclonal ELISA,IHC-P 50093-RP02
    Anti-Fetuin A Antibody Rabbit Monoclonal ELISA(Cap) 50093-R012
    Anti-Fetuin A Antibody Rabbit Monoclonal ELISA 50093-R002
    Anti-Fetuin A Antibody Rabbit Polyclonal ELISA 50093-RP01
    Anti-Fetuin A Antibody Rabbit Monoclonal ELISA,ELISA(Det),ICC/IF,IF 10318-R001
    Anti-Fetuin A Antibody Rabbit Polyclonal ELISA 10318-T16
    Anti-Fetuin A Antibody Rabbit Polyclonal ELISA 10318-RP01
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