Anti-Fetuin A Antibody

Cat: 50093-RP01
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All Fetuin A Reagents
CRO Services
Product recommended

All Fetuin A Reagents
Anti-Fetuin A Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Fetuin A Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Fetuin A
Immunogen
Recombinant Mouse Fetuin-A / AHSG protein (Catalog#50093-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Fetuin-A / AHSG (rM Fetuin-A / AHSG; Catalog#50093-M08H; NP_032037.2; Met 1-Ile 345). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Fetuin A Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Fetuin A Background Information

Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.

Full Name
alpha-2-HS-glycoprotein
References
  • Mehrotra R. (2007) Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int. 72(2): 137-40.
  • Westenfeld R, et al. (2007) Vascular calcification and fetuin-A deficiency in chronic kidney disease. Trends Cardiovasc Med. 17(4): 124-8.
  • Heiss A, et al. (2008). Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J Biol Chem. 283 (21): 14815-25.
  • Jahnen-Dechent W, et al. (2008). Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification. J Mol Med. 86 (4): 379-89.
  • Hedrich J, et al. (2010) Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. Biochemistry. 49(39): 8599-607.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Fetuin A Antibody Rabbit Monoclonal IHC-P 50093-R022
    Anti-Fetuin A Antibody Rabbit Polyclonal ELISA,IHC-P 50093-RP02
    Anti-Fetuin A Antibody Rabbit Monoclonal ELISA(Cap) 50093-R012
    Anti-Fetuin A Antibody Rabbit Monoclonal ELISA 50093-R002
    Anti-Fetuin A Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10318-MM02
    Anti-Fetuin A Antibody Rabbit Monoclonal ELISA,ELISA(Det),ICC/IF,IF 10318-R001
    Anti-Fetuin A Antibody Rabbit Polyclonal ELISA 10318-T16
    Anti-Fetuin A Antibody Rabbit Polyclonal ELISA 10318-RP01
    info info
    添加购物车成功! 添加购物车失败!