|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Ferret B2M ORF mammalian expression plasmid, C-GFPSpark tag||FG60069-ACG|
|Ferret B2M ORF mammalian expression plasmid, C-OFPSpark / RFP tag||FG60069-ACR|
|Ferret B2M ORF mammalian expression plasmid, C-Flag tag||FG60069-CF|
|Ferret B2M ORF mammalian expression plasmid, C-His tag||FG60069-CH|
|Ferret B2M ORF mammalian expression plasmid, C-Myc tag||FG60069-CM|
|Ferret B2M ORF mammalian expression plasmid, C-HA tag||FG60069-CY|
|Ferret B2M Gene cDNA clone plasmid||FG60069-G|
|Ferret B2M ORF mammalian expression plasmid, N-Flag tag||FG60069-NF|
|Ferret B2M ORF mammalian expression plasmid, N-His tag||FG60069-NH|
|Ferret B2M ORF mammalian expression plasmid, N-Myc tag||FG60069-NM|
|Ferret B2M ORF mammalian expression plasmid, N-HA tag||FG60069-NY|
|Ferret B2M natural ORF mammalian expression plasmid||FG60069-UT|
|Learn more about expression Vectors|
B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.