Fc alapha receptor / FCAR / FcαR

Fc alpha receptor definition

Fc alpha receptor (FcαR) is the receptor specific for IgA which binds IgA with low affinity. There is only one type belonging to the Fc alpha receptor subgroup, which is called FcαRI (CD89). Fc alpha receptor I is expressed on neutrophils, eosinophils, monocytes/macrophages, dendritic cells and Kupffer cells.

Fc alpha receptor

A number of cytokines and other agents modulate Fc alpha receptor I expression, such as IL-1β, IL-8, THF-α. In contrast to other Fc receptors, Fc alpha receptor I expression is downregulated by polymeric IgA.

Fc alpha receptor signaling

Fc alpha receptor is a member of the multichain immune recognition receptor (MIRR) family. Fc alpha receptor is composed of two extracellular Ig-like domains, α-chain and γ-chain. Fc alpha receptor I γ-chain contains a so-called ITAM (immunoreceptor tyrosine-based activation motif) signaling motif. Fc alpha receptor I with ITAM activates sequentially src family tyrosine kinases and syk family tyrosine kinases and mediates endocytosis, ADCC and recyling of IgA. Signaling is dependent on association of FcαRI with another FcαRI γ-chain subunit, forming the trimmer FcαRIα/γγ.

23000+ Products

Proteins
Antibodies
ELISA Kits
cDNA Clones
Fc Receptor

Fc receptor Information

What is Fc receptor
Fc receptor function
Classes of Fc receptor

    --Fc alpha receptor (FCAR / FcαR)
    --Fc gamma receptor (FCGR / FcγR)
    --Fc epsilon recepto (FCER / FcεR)
    --Neonatal Fc receptor (FCGRT)
    --Fc Receptor-Like protein (FCRL / FCRH)
    --Fcα/μR (FCAMR)

Fc Receptor Reagents

CD16 / FCGR3
CD16-2/FCGR4
CD16a / FCGR3A
CD16b / FCGR3B
CD23 / FCER2
CD32a / FCGR2A
CD32b / FCGR2B
CD64 / FCGR1
CD89 / FCAR
FCAMR
FCER1G
FcERI / FCER1A
FCGRT
FCGRT & B2M
FCRL1 / FCRH1
FCRL3
FCRL4