Fc Receptor / Fc Receptors

An Fc receptor is a protein found on the surface of certain cells - including natural killer cells, macrophages, neutrophils, and mast cells - that contribute to the protective functions of the immune system. Its name is derived from its binding specificity for a part of an antibody known as the Fc (Fragment, crystallizable) region. Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. Some viruses such as flaviviruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection.

Products of Sino Biological

Fc Receptor Products

Quality proteins, antibodies, ELISA pair sets, cDNA clones for Fc receptor related studies

Fc Receptor Protein

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
FCAR/CD89	Human	Fc alpha Receptor/CD89 Protein, Recombinant	10414-H08H
FCAR/CD89	Rat	Fc alpha Receptor/CD89 Protein, Recombinant	80014-R08H
FCGR1/CD64	Human	Fc gamma Receptor I/CD64 Protein, Recombinant	10256-H08H
FCGR1/CD64	Human	Fc gamma Receptor I/CD64 Protein, Recombinant, with AVI Tag	10256-H27H
FCGR1/CD64	Human	Fc gamma Receptor I/CD64 Protein, Recombinant, with AVI Tag, Biotinylated	10256-H27H-B
FCGR1/CD64	Mouse	Fc gamma Receptor I/CD64 Protein, Recombinant	50086-M08H
FCGR1/CD64	Mouse	Fc gamma Receptor I/CD64 Protein, Recombinant, with AVI Tag	50086-M27H
FCGR1/CD64	Mouse	Fc gamma Receptor I/CD64 Protein, Recombinant, with AVI Tag, Biotinylated	50086-M27H-B
FCGR1/CD64	Rat	Fc gamma Receptor I/CD64 Protein, Recombinant	80016-R08H
FCGR2/CD32	Mouse	Fc gamma Receptor II/CD32 Protein, Recombinant	50030-M08H
FCGR2/CD32	Mouse	Fc gamma Receptor II/CD32 Protein, Recombinant, with AVI Tag	50030-M27H
FCGR2/CD32	Mouse	Fc gamma Receptor II/CD32 Protein, Recombinant, with AVI Tag, Biotinylated	50030-M27H-B
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein, Recombinant (Fc tag)	10374-H02H
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein, Recombinant	10374-H08H
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein, Recombinant	10374-H08B
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein, Recombinant	10374-H08C
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein (167 Arg/His), Recombinant	10374-H08H1
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein, Recombinant, with AVI Tag	10374-H27H
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein (167 Arg/His), Recombinant, with AVI Tag	10374-H27H1
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein, Recombinant, with AVI Tag, Biotinylated	10374-H27H-B
FCGR2A/CD32a	Human	Fc gamma Receptor IIA/CD32a Protein (131 Arg/His), Recombinant, with AVI Tag, Biotinylated	10374-H27H1-B
FCGR2A/CD32a	Cynomolgus	Fc gamma Receptor IIA/CD32a Protein, Recombinant	90015-C08H
FCGR2A/CD32a	Cynomolgus	Fc gamma Receptor IIA/CD32a Protein, Recombinant, with AVI Tag	90015-C27H
FCGR2A/CD32a	Cynomolgus	Fc gamma Receptor IIA/CD32a Protein, Recombinant, with AVI Tag, Biotinylated	90015-C27H-B
FCGR2A/CD32a	Cynomolgus	Fc gamma Receptor IIA/CD32a Protein, Recombinant	90016-C08H
FCGR2B/CD32b	Human	Fc gamma Receptor IIB/CD32b Protein, Recombinant	10259-H08C
FCGR2B/CD32b	Human	Fc gamma Receptor IIB/CD32b Protein, Recombinant	10259-H08H
FCGR2B/CD32b	Human	Fc gamma Receptor IIB/CD32b Protein, Recombinant with AVI Tag	10259-H27H
FCGR2B/CD32b	Human	Fc gamma Receptor IIB/CD32b Protein, Recombinant, with AVI Tag, Biotinylated	10259-H27H-B
FCGR2B/CD32b	Rat	Fc gamma Receptor IIB/CD32b Protein, Recombinant	80018-R08H
FCGR2B/CD32b	Cynomolgus	Fc gamma Receptor IIB/CD32b Protein, Recombinant	90014-C08H
FCGR2B/CD32b	Cynomolgus	Fc gamma Receptor IIB/CD32b Protein, Recombinant, with AVI Tag	90014-C27H
FCGR2B/CD32b	Cynomolgus	Fc gamma Receptor IIB/CD32b Protein, Recombinant, with AVI Tag, Biotinylated	90014-C27H-B
FCGR3/CD16	Mouse	Fc gamma Receptor III/CD16 Protein, Recombinant	50326-M08H
FCGR3/CD16	Cynomolgus	Fc gamma Receptor III/CD16 Protein, Recombinant	90013-C08H
FCGR3/CD16	Cynomolgus	Fc gamma Receptor III/CD16 Protein, Recombinant, with AVI Tag	90013-C27H
FCGR3/CD16	Cynomolgus	Fc gamma Receptor III/CD16 Protein, Recombinant, with AVI Tag, Biotinylated	90013-C27H-B
FCGR3A/CD16a	Human	Fc gamma Receptor IIIA/CD16a Protein, Recombinant	10389-H08H
FCGR3A/CD16a	Human	Fc gamma Receptor IIIA/CD16a Protein (176 Phe/Val), Recombinant	10389-H08H1
FCGR3A/CD16a	Human	Fc gamma Receptor IIIA/CD16a Protein , Recombinant	10389-H08C
FCGR3A/CD16a	Human	Fc gamma Receptor IIIA/CD16a Protein (176 Phe/Val), Recombinant	10389-H08C1
FCGR3A/CD16a	Human	Fc gamma Receptor IIIA/CD16a Protein, Recombinant, with AVI Tag	10389-H27H
FCGR3A/CD16a	Human	Fc gamma Receptor IIIA/CD16a Protein (176 Phe/Val), Recombinant, with AVI Tag	10389-H27H1
FCGR3A/CD16a	Human	Fc gamma Receptor IIIA/CD16a Protein, Recombinant, with AVI Tag, Biotinylated	10389-H27H-B
FCGR3A/CD16a	Human	Fc gamma Receptor IIIA/CD16a (158 Phe/Val) Protein, Recombinant, with AVI Tag, Biotinylated	10389-H27H1-B
FCGR3A/CD16a	Rat	Fc gamma Receptor IIIA/CD16a Protein, Recombinant	80017-R08H
FCGR3B/CD16b	Human	Fc gamma Receptor IIIB/CD16b Protein, Recombinant, Native	11046-H08H
FCGR3B/CD16b	Human	Fc gamma Receptor IIIB/CD16b Protein, Recombinant, Native	11046-H08C
FCGR3B/CD16b	Human	Fc gamma Receptor IIIB/CD16b Protein, Recombinant, Native	11046-HNAE
FCGR4/CD16-2	Mouse	Fc gamma Receptor IV/CD16-2 Protein, Recombinant	50036-M08H
FCGR4/CD16-2	Mouse	Fc gamma Receptor IV/CD16-2 Protein, Recombinant, with AVI Tag	50036-M27H
FCGR4/CD16-2	Mouse	Fc gamma Receptor IV/CD16-2 Protein, Recombinant, with AVI Tag, Biotinylated	50036-M27H-B
FCRL1/FCRH1	Human	Fc Receptor-Like 1/Fc Receptor Homolog 1 Protein, Recombinant	11536-H08H
FCER2/CD23	Human	Fc fragment of IgE, low affinity II, Receptor Protein, Recombinant	10261-H07H
FCER2/CD23	Mouse	Fc fragment of IgE, low affinity II, Receptor Protein, Recombinant	50695-M07H

Fc Receptor Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human FCAR/CD89	ELISA	Fc alpha Receptor/CD89 Antibody, Mouse MAb	10414-MM02
Human FCAR/CD89	WB, ELISA	Fc alpha Receptor/CD89 Antibody, Rabbit MAb	10414-R006
Human FCAR/CD89	WB, ELISA	Fc alpha Receptor/CD89 Antibody, Rabbit PAb	10414-RP01
Human FCAR/CD89	WB, ELISA	Fc alpha Receptor/CD89 Antibody, Rabbit PAb (Antigen Affinity Purified)	10414-RP02
Rat FCAR/CD89	WB, ELISA	Fc alpha Receptor/CD89 Antibody, Rabbit PAb	80014-RP01
Rat FCAR/CD89	WB, ELISA	Fc alpha Receptor/CD89 Antibody, Rabbit PAb (Antigen Affinity Purified)	80014-RP02
Human FCGR1/CD64	ELISA	Fc gamma Receptor I/CD64 Antibody, Mouse MAb	10256-MM06
Human FCGR1/CD64	WB	Fc gamma Receptor I/CD64 Antibody, Mouse MAb	10256-MM07
Human FCGR1/CD64	WB, ELISA	Fc gamma Receptor I/CD64 Antibody, Rabbit PAb	10256-RP01
Human FCGR1/CD64	WB, ELISA	Fc gamma Receptor I/CD64 Antibody, Rabbit PAb (Antigen Affinity Purified)	10256-RP02
Mouse FCGR1/CD64	WB, ELISA	Fc gamma Receptor I/CD64 Antibody, Rabbit MAb	50086-R001
Mouse FCGR1/CD64	WB, ELISA, IHC-P	Fc gamma Receptor I/CD64 Antibody, Rabbit MAb	50086-R008
Mouse FCGR1/CD64	WB, ELISA	Fc gamma Receptor I/CD64 Antibody, Rabbit PAb	50086-RP01
Mouse FCGR1/CD64	WB, ELISA	Fc gamma Receptor I/CD64 Antibody, Rabbit PAb (Antigen Affinity Purified)	50086-RP02
Mouse FCGR2/CD32	WB, ELISA	Fc gamma Receptor II/CD32 Antibody, Rabbit MAb	50030-R005
Mouse FCGR2/CD32	ELISA	Fc gamma Receptor II/CD32 Antibody, Rabbit PAb	50030-RP01
Mouse FCGR2/CD32	WB, ELISA	Fc gamma Receptor II/CD32 Antibody, Rabbit PAb (Antigen Affinity Purified)	50030-RP02
Human FCGR2A/CD32a	ELISA	Fc gamma Receptor IIA/CD32a Antibody, Mouse MAb	10374-MM01
Human FCGR2A/CD32a	ELISA	Fc gamma Receptor IIA/CD32a Antibody, Mouse MAb	10374-MM02
Human FCGR2A/CD32a	WB, ELISA	Fc gamma Receptor IIA/CD32a Antibody, Mouse MAb	10374-MM03
Human FCGR2A/CD32a	WB, ELISA	Fc gamma Receptor RIIA/CD32a Antibody, Rabbit PAb	10374-RP01
Human FCGR2B/CD32b	WB, ELISA	Fc gamma Receptor IIB/CD32b Antibody, Mouse MAb	10259-MM02
Human CD32b/FCGR2B	WB, ELISA	Fc gamma Receptor IIB/CD32b Antibody, Rabbit Mab	10259-R112
Human CD32b/FCGR2B	IHC	Fc gamma Receptor IIB/CD32b Antibody, Rabbit Mab	10259-R110
Human FCGR2B/CD32b	WB, ELISA	Fc gamma Receptor IIB/CD32b Antibody, Rabbit PAb	10259-RP01
Human FCGR2B/CD32b	WB, ELISA	Fc gamma Receptor IIB/CD32b Antibody, Rabbit PAb (Antigen Affinity Purified)	10259-RP03
Rat FCGR2B/CD32b	WB, ELISA	Fc gamma Receptor IIB/CD32b Antibody, Rabbit PAb	80018-RP01
Rat FCGR2B/CD32b	WB, ELISA	Fc gamma Receptor IIB/CD32b Antibody, Rabbit PAb (Antigen Affinity Purified)	80018-RP02
Cynomolgus FCGR2B/CD32b	WB, ELISA	Fc gamma Receptor IIB/CD32b Antibody, Rabbit PAb (Antigen Affinity Purified)	90014-RP02
Mouse FCGR3A/CD16	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Rabbit PAb	50326-RP01
Mouse FCGR3A/CD16	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Rabbit PAb	50326-RP02
Mouse FCGR3A/CD16	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Rabbit MAb	50326-R015
Cynomolgus FCGR3A/CD16	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Mouse MAb	90013-MM01
Cynomolgus FCGR3A/CD16	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Rabbit PAb	90013-RP02
Rat FCGR3A/CD16a	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Mouse MAb	80017-MM06
Rat FCGR3A/CD16a	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Rabbit PAb	80017-RP02
Human FCGR3A/CD16a	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Mouse MAb	10389-MM02
Human FCGR3A/CD16a	ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Mouse MAb	10389-MM03
Human FCGR3A/CD16a	WB, ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Rabbit PAb	10389-RP01
Human FCGR3A/CD16a	WB, ELISA	Fc gamma Receptor IIIA/CD16a Antibody, Rabbit PAb (Antigen Affinity Purified)	10389-RP02
Human FCGR3B/CD16b	ELISA	Fc gamma Receptor IIIB/CD16b Antibody, Mouse MAb	11046-MM01
Human FCGR3B/CD16b	WB	Fc gamma Receptor IIIB/CD16b Antibody, Mouse MAb	11046-MM04
Human FCGR3B/CD16b	WB	Fc gamma Receptor IIIB/CD16b Antibody, Mouse MAb	11046-MM09
Human FCGR3B/CD16b	WB, ELISA	Fc gamma Receptor IIIB/CD16b Antibody, Rabbit PAb	11046-RP01
Human FCGR3B/CD16b	WB, ELISA	Fc gamma Receptor IIIB/CD16b Antibody, Rabbit PAb (Antigen Affinity Purified)	11046-RP02
Mouse FCGR4/CD16-2	WB, ELISA	Fc gamma Receptor IV/CD16-2 Antibody, Rabbit MAb	50036-R012
Mouse FCGR4/CD16-2	WB, ELISA	Fc gamma Receptor IV/CD16-2 Antibody, Rabbit PAb	50036-RP01
Mouse FCGR4/CD16-2	WB, ELISA	Fc gamma Receptor IV/CD16-2 Antibody, Rabbit PAb (Antigen Affinity Purified)	50036-RP02
Mouse FCGR4/CD16-2	WB, ELISA	Fc gamma Receptor IV/CD16-2 Antibody, Rabbit MAb (Antigen Affinity Purified)	50036-R011
Mouse FCGR4/CD16-2	WB, ELISA	Fc gamma Receptor IV/CD16-2 Antibody, Rabbit MAb ( FITC )	50036-R012-F
Human FCRL1/FCRH1	WB, ELISA	FCRL1 / FCRH1 Antibody , Rabbit PAb (Antigen Affinity Purified)	11536-RP02
Mouse CD23/FCER2	WB, ELISA	CD23 / FCER2 Antibody, Rabbit PAb	50695-RP01
Mouse CD23/FCER2	WB, ELISA	CD23 / FCER2 Antibody, Rabbit PAb (Antigen Affinity Purified)	50695-RP02

Fc Receptor ELISA Kit

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
FCGR2B/CD32b	Human	Fc gamma Receptor IIB / CD32b ELISA Kit	SEK10259
FCGR2B/CD32b	Human	Fc gamma Receptor IIB / CD32b ELISA Kit	SEKA10259
CD89/FCAR	Human	Fc alpha Receptor / CD89 ELISA Kit	SEK10414

Fc Receptor cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
FCAMR	Mouse	Mouse FCAMR cDNA clone(NM_001170632.1)	MG51089-G
FCAMR	Rat	Rat FCAMR cDNA clone(XM_001060181.2)	RG80095-G
FCAR/CD89	Human	Homo sapiens FCAR/CD89 transcript variant 1 cDNA Clone(NM_002000.2)	HG10414-M
FCAR/CD89	Rat	Rattus norvegicus FCAR/CD89 cDNA Clone (NM_201992.1)	RG80014-M
FCER2/CD23	Human	Homo sapiens FCER2/CD23 cDNA Clone (NM_002002.3)	HG10261-M
FCGR1/CD64	Human	Homo sapiens FCGR1/CD64 cDNA Clone (NM_000566.3)	HG10256-M
FCGR1/CD64	Mouse	Mus musculus FCGR1/CD64 cDNA Clone (NM_010186.5)	MG50086-M
FCGR1/CD64	Rat	Rattus norvegicus FCGR1/CD64 cDNA Clone (NM_001100836.1)	RG80016-M
FCGR1/CD64	Cynomolgus	Cynomolgus monkey CD64/FCGR1 cDNA Clone / ORF Clone	CG90017-M
FCGR2A/CD32a	Human	Homo sapiens FCGR2A/CD32a transcript variant 1 cDNA Clone(NM_001136219.1)	HG10374-M
FCGR2A/CD32a	Rat	Rattus norvegicus FCGR2A/CD32a cDNA Clone (NM_053843.2)	RG80015-M
FCGR2A/CD32a	Cynomolgus	Cynomolgus monkey CD32a/FCGR2A cDNA Clone / ORF Clone	CG90016-M
FCGR2B/CD32b	Human	Homo sapiens FCGR2B/CD32b transcript variant 3 cDNA Clone(NM_001002274.1)	HG10259-M
FCGR2B/CD32b	Human	Homo sapiens FCGR2B/CD32b transcript variant 2 cDNA Clone(NM_001002273.1)	HG10260-M
FCGR2B/CD32b	Cynomolgus	Cynomolgus monkey CD32b/FCGR2B cDNA Clone / ORF Clone	CG90014-M
FCGR3/CD16	Cynomolgus	Cynomolgus monkey CD16/FCGR3 cDNA Clone / ORF Clone	CG90013-M
FCGR3A/CD16a	Human	Homo sapiens FCGR3A/CD16a transcript variant 5 cDNA Clone(NM_001127596.1)	HG10389-M
FCGR3A/CD16a	Rat	Rattus norvegicus FCGR3A/CD16a cDNA Clone (NM_207603.1)	RG80017-M
FCGR4/CD16-2	Mouse	Mus musculus FCGR4/CD16-2 cDNA Clone (NM_144559.1)	MG50036-M
FCRL1/FCRH1	Human	Homo sapiens FCRL1/FCRH1 cDNA Clone (9NM_052938.4)	HG11536-M
FCRL1/FCRH1	Mouse	Mouse FCRL1/FCRH1 cDNA Clone / ORF Clone	MG50947-G
FCRL3/FCRH3	Human	Homo sapiens FCRL3/FCRH3 cDNA Clone (NM_052939.3)	HG11254-M
CD23/FCER2	Human	Human CD23/FCER2 cDNA Clone / ORF Clone (NM_002002.3 )	HG10261-M
CD23/FCER2	Mouse	Mouse CD23/FCER2 cDNA Clone / ORF Clone (NM_013517.4)	MG50695-G
CD23/FCER2	Rat	Rat CD23/FCER2 cDNA Clone / ORF Clone (NM_001033924.1)	RG80208-G

Fc Receptor Background

Fc Receptors

Classes of Fc receptor

There are several different types of Fc receptors, which are classified based on the type of antibody that they recognize. The Latin letter used to identify a type of antibody is converted into the corresponding Greek letter, which is placed after the 'Fc' part of the name. For example, those that bind the most common class of antibody, IgG, are called Fc-gamma receptors(FcγR), those that bind IgA are called Fc-alpha receptors (FcαR) and those that bind IgE are called Fc-epsilon receptors (FcεR).

Fc-gamma receptors All FcγRs belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing phagocytosis of opsonized (coated) microbes. This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which differ in their antibody affinities due to their different molecular structure.For instance, FcγRI binds to IgG more strongly than FcγRII or FcγRIII does. FcγRI also has an extracellular portion composed of three immunoglobulin (Ig)-like domains, one more domain than FcγRII or FcγRIII has. This property allows activation of FcγRI by a sole IgG molecule (or monomer), while the latter two Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated.

Another FcR is expressed on multiple cell types and is similar in structure to MHC class I. This receptor also binds IgG and is involved in preservation of this antibody. However, since this Fc receptor is also involved in transferring IgG from a mother either via the placenta to her fetus or in milk to her suckling infant, it is called the neonatal Fc receptor (FcRn).Recently, research suggested that this receptor plays a role in the homeostasis of IgG serum levels.

Fc-alpha receptors Only one Fc receptor belongs to the FcαR subgroup, which is called FcαRI (or CD89). FcαRI is found on the surface of neutrophils, eosinophils, monocytes, some macrophages (including Kupffer cells), and some dendritic cells.It is composed of two extracellular Ig-like domains, and is a member of both the immunoglobulin superfamily and the multi-chain immune recognition receptor (MIRR) family.It signals by associating with two FcRγ signaling chains.Another receptor can also bind IgA, although it has higher affinity for another antibody called IgM.This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its extracellular portion, this Fc receptor is also a member of the immunoglobulin superfamily.

Fc-epsilon receptors The high-affinity receptor FcεRI is a member of the immunoglobulin superfamily (it has two Ig-like domains). FcεRI is found on epidermal Langerhans cells, eosinophils, mast cells and basophils.As a result of its cellular distribution, this receptor plays a major role in controlling allergic responses. FcεRI is also expressed on antigen-presenting cells, and controls the production of important immune mediators called cytokines that promote inflammation.

The low-affinity receptor FcεRII (CD23) is a C-type lectin. FcεRII has multiple functions as a membrane-bound or soluble receptor; it controls B cell growth and differentiation and blocks IgE-binding of eosinophils, monocytes, and basophils.

Fc Receptor Related Studies

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Firan M, Bawdon R,et al. (2001).Int Immunol 13 (8): 993–1002.
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Otten M, van Egmond M (2004).Immunol Lett 92 (1-2): 23–31.
Shibuya A, Honda S (2006).Springer Semin Immunopathol 28 (4): 377–82.
Cho Y, Usui K, et al. (2006).Biochem Biophys Res Commun 345 (1): 474–8.
Ochiai K, et al. (1994). Int Arch Allergy Immunol 104 Suppl 1 (1): 63–4.
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