FUT8

Human alpha (1,6) fucosyltransferase 8, also known as FUT8, is a member of the glycosyltransferase family. Fucosyltransferases are the enzymes transferring fucose from GDP-Fuc to Gal in an alpha1,2-linkage and to GlcNAc in alpha1,3-linkage, alpha1,4-linkage, or alpha1,6-linkage. All fucosyltransferases utilize the same nucleotide sugar, their specificity reside in the recognition of the acceptor and in the type of linkage formed. Fucosyltransferases share some common structural and catalytic features. On the basis of protein sequence similarities, these enzymes can be classified into four distinct families: (1) the alpha-2-fucosyltransferases, (2) the alpha-3-fucosyltransferases, (3) the mammalian alpha-6-fucosyltransferases, and (4) the bacterial alpha-6-fucosyltransferases. The alpha-3-fucosyltransferases constitute a distinct family as they lack the consensus peptide, but some regions display similarities with the alpha-2 and alpha-6-fucosyltranferases.

FUT8 Related Areas

Enzyme>>Carbohydrate Metabolism Enzymes>>FUT8

FUT8 Alternative Names

MGC26465[Homo sapiens]

GDP-L-Fuc, N-acetyl-beta-D-glucosaminide alpha1, 6-fucosyltransferase[Mus musculus]

Summaries for FUT8

Entrez Gene summary for FUT8:

This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.

OMIM - description for FUT8:

The FUT8 gene encodes alpha-1,6-fucosyltransferase (EC 2.4.1.68), which catalyzes the transfer of fucose to N-linked glycopeptides.

Wikipedia summary for FUT8:

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified

Human FUT8 Protein General Information

 

• Protein names: Recommended name: Alpha-(1,6)-fucosyltransferase Short name=alpha1-6FucT
• Sequence length: 575 AA.
• Domain: SH3 domain SH3-binding Signal-anchor Transmembrane Transmembrane helix
• Sequence similarities: Belongs to the glycosyltransferase 23 family. Contains 1 SH3 domain.
• Catalytic activity: GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.
• Pathway: Protein modification; protein glycosylation.
• Subcellular location: Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi

General information above from UniProt

Function for FUT8 Protein

UniProtKB:

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

Genatlas:

• FUT8 is involved in the biosynthesis of asparagine-linked glycoprotein oligosaccharides