Anti-FSTL1 Antibody

Cat: 10924-RP02
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Anti-FSTL1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-FSTL1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human FSTL1
Immunogen
Recombinant Human FSTL1 protein (Catalog#10924-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human FSTL1 / FRP (rh FSTL1; Catalog#10924-H08H; NP_009016.1; Met 1-Ile 308). FSTL1 specific IgG was purified by human FSTL1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FSTL1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-FSTL1 Antibody Alternative Names
Anti-FRP Antibody;Anti-FSL1 Antibody;Anti-MIR198 Antibody
FSTL1 Background Information

Follistatin-related protein 1 (FSTL1)  is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

Full Name
follistatin-like 1
References
  • Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
  • Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
  • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-FSTL1 Antibody Rabbit Polyclonal ELISA 80885-RP01
    Anti-FSTL1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 80885-T60
    Anti-FSTL1 Antibody Mouse Monoclonal ELISA 80885-MM12
    Anti-FSTL1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 51127-T56
    Anti-FSTL1 Antibody Rabbit Polyclonal ELISA 51127-RP01
    Anti-FSTL1 Antibody Rabbit Polyclonal WB,ELISA 51127-T48
    Anti-FSTL1 Antibody (FITC) Rabbit Monoclonal FCM 10924-R009-F
    Anti-FSTL1 Antibody Rabbit Monoclonal ICC/IF,IF 10924-R026
    Anti-FSTL1 Antibody Mouse Monoclonal ELISA 10924-MM09
    Anti-FSTL1 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 10924-R009
    Anti-FSTL1 Antibody Rabbit Polyclonal ELISA 10924-RP01
    Anti-FSTL1 Antibody Rabbit Monoclonal ELISA 80885-R011
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