Anti-FOLR2 Antibody

Cat: 11219-RP02
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Anti-FOLR2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-FOLR2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human FOLR2
Immunogen
Recombinant Human FOLR2 protein (Catalog#11219-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human FOLR2 (rh FOLR2; Catalog#11219-H08H; P14207-1; Met 1-His 228). FOLR2 specific IgG was purified by Human FOLR2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FOLR2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-FOLR2 Antibody Alternative Names
Anti-BETA-HFR Antibody;Anti-FBP Antibody;Anti-FBP/PL-1 Antibody;Anti-FR-BETA Antibody;Anti-FR-P3 Antibody
FOLR2 Background Information

Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

Full Name
folate receptor 2 (fetal)
References
  • van Heyningen V, et al., 1995, Cytogenet Cell Genet. 69 (3-4): 127-58.
  • Sabharanjak, S. et al., 2004, Adv Drug Deliv Rev. 56 (8): 1099-109. 
  • Scapoli, L. et al., 2005, Am J Med Genet A. 132A (3): 302-4.
  • Puig-Kröger, A. et al., 2009, Cancer Res  69 (24): 9395-403.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-FOLR2 Antibody Rabbit Monoclonal ELISA 11219-R046
    Anti-FOLR2 Antibody Rabbit Monoclonal IHC-P 11219-R001
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