Anti-FOLR2 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human FOLR2 protein (Catalog#11219-H08H)
Produced in rabbits immunized with purified, recombinant Human FOLR2 (rh FOLR2; Catalog#11219-H08H; P14207-1; Met 1-His 228). FOLR2 specific IgG was purified by Human FOLR2 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FOLR2 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-FOLR2 Antibody Alternative Names
Anti-BETA-HFR Antibody;Anti-FBP Antibody;Anti-FBP/PL-1 Antibody;Anti-FR-BETA Antibody;Anti-FR-P3 Antibody
FOLR2 Background Information
Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
folate receptor 2 (fetal)
van Heyningen V, et al., 1995, Cytogenet Cell Genet. 69 (3-4): 127-58. Sabharanjak, S. et al., 2004, Adv Drug Deliv Rev. 56 (8): 1099-109. Scapoli, L. et al., 2005, Am J Med Genet A. 132A (3): 302-4. Puig-Kröger, A. et al., 2009, Cancer Res 69 (24): 9395-403.