Anti-FOLR1 Antibody

Cat: 50573-RP01

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Anti-FOLR1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-FOLR1 Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse FOLR1
Recombinant Mouse FOLR1 protein (Catalog#50573-M08H)
Produced in rabbits immunized with purified, recombinant Mouse FOLR1 (rM FOLR1; Catalog#50573-M08H; NP_032060.2; Met 1-Met 231). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FOLR1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-FOLR1 Antibody Alternative Names
Anti-FBP1 Antibody;Anti-Folbp-1 Antibody;Anti-Folbp1 Antibody
FOLR1 Background Information

The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
Folate receptor α (FRα) is the most important subunit of Folate receptor and the alpha isoform has been shown to be selectively overexpressed in cancer types like breast and ovarian cancer compared to normal breast and ovarian epithelial cells. It was determined that Folate receptor α exhibits a limited expression on the apical surfaces of the epithelial cells of normal lung, breast, thyroid, parathyroid, and kidney tissues. For their uptake of folate, normal cells rely almost exclusively on the reduced folate carrier, whereas many carcinomas and myeloid leukemia cells overexpress a high-affinity FR on their surfaces, perhaps reflecting their increased need for folate to support rapid cell division

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
folate receptor 1 (adult)
Research Areas
  • Senol S, Ceyran AB, Aydin A, et al. Folate receptor α expression and significance in endometrioid endometrium carcinoma and endometrial hyperplasia. International Journal of Clinical and Experimental Pathology. 2015;8(5):5633-5641.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-FOLR1 Antibody Rabbit Polyclonal ELISA 70115-T16
    Anti-FOLR1 Antibody Rabbit Polyclonal ELISA 70115-RP01
    Anti-FOLR1 Antibody Rabbit Polyclonal ELISA 81073-RP01
    Anti-FOLR1 Antibody Rabbit Polyclonal WB,IHC-P 81073-T40
    Anti-FOLR1 Antibody Rabbit Polyclonal ELISA 50573-RP02
    Anti-FOLR1 Antibody Rabbit Polyclonal ELISA,IHC-P,ICC/IF,IF 11241-T26
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