FLT-3 / CD135 Protein & Antibody (FLK-2)

Fms-related tyrosine kinase 3 / Cluster of Differentiation 135 (Fetal Liver Kinase 2)

FLT3 / CD135 Products

FLT3 / CD135 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
FLT3/CD135/FLK2	Human	FLT3/CD135/FLK2 Protein, Recombinant	10445-H08H

FLT3 / CD135 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human FLT-3/CD135/FLK-2	FCM	FLT3 / CD135 / FLK2 Antibody ( FITC )	10445-MM02-F
Human FLT-3/CD135/FLK-2	WB, ELISA	FLT-3/CD135/FLK-2 Antibody, Mouse MAb	10445-MM05
Human FLT-3/CD135/FLK-2	WB, ELISA	FLT-3/CD135/FLK-2 Antibody, Rabbit PAb	10445-RP01
Human FLT-3/CD135/FLK-2	WB, ELISA	FLT-3/CD135/FLK-2 Antibody, Rabbit PAb (Antigen Affinity Purified)	10445-RP02

FLT3 / CD135 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
FLT3/CD135/FLK2	Human	Homo sapiens FLT3/CD135/FLK2 cDNA Clone(NM_004119.2)	HG10445-M
FLT3/CD135/FLK2	Cynomolgus	Cynomolgus monkey FLT3 Gene cDNA Clone / ORF Clone	CG90219-G

FLT3 / CD135 Alternative Names

FLT3, CD135, FLK2, RP11-153M24.3, STK1 [Homo sapiens]

Flt-3, CD135, Flk-2, Flk2, Flt3, B230315G04, Ly72, MGC124377, MGC124378 [Mus musculus]

FLT3 / CD135 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FLT3/CD135/FLK2

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FLT3/CD135/FLK2

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>FLT3/CD135/FLK2

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FLT3/CD135/FLK2

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>FLT3/CD135/FLK2

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>FLT3/CD135/FLK2

FLT3 / CD135 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD135, also known as FLT-3, FLK-2, is a member of the CD system. CD135 is an important cell surface marker recognized by specific sets of antibodies to identify the types of hematopoietic (blood) progenitors in the bone marrow and it function to differentiate hematopoietic stem cells, which are CD135 negative, from multipotent progenitors, which are CD135 positive. CD135 is a receptor tyrosine kinase typeⅢ for the cytokine Flt3 ligand and activat signaling through second messengers by binding to Flt3. Signaling through CD135 is important for lymphocyte development. The encoding gene CD135 is a proto-oncogene to which mutations happened will lead to cancer such as leukemia.

FLT3 / CD135 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4.  Bertho, et al. (2000) CD135 (Flk2 / Flt3) Expression by Human Thymocytes Delineates a Possible Role of FLT3-Ligand in T-Cell Precursor Proliferation and Differentiation. Scandinavian Journal of Immunology. 52 (1): 53-61.