FLRT3 Protein & Antibody

Fibronectin leucine rich transmembrane protein 3

FLRT3 Products

FLRT3 Protein, Recombinant

Molecule	Species	Description	Cat. No
FLRT3	Human	FLRT3 Protein, Recombinant	11166-H08H

FLRT3 Antibody

Molecule	Application	Description	Cat. No
Human FLRT3	WB, ELISA	FLRT3 Antibody, Rabbit PAb	11166-RP01
Human FLRT3	WB, ELISA	FLRT3 Antibody, Rabbit PAb (Antigen Affinity Purified)	11166-RP02

FLRT3 cDNA Clone

Molecule	Species	Description	Cat. No
FLRT3	Human	Homo sapiens FLRT3 cDNA Clone	HG11166-M

FLRT3 Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>FLRT3

FLRT3 Alternative Names

FLRT3, UNQ856/PRO1865 [Homo sapiens]

Flrt3, RP23-388J20.1, 5530600M07Rik, C430047I10Rik, mKIAA1469 [Mus musculus]

FLRT3 Background

Leucine-rich repeat transmembrane protein FLRT3, also known as Fibronectin-like domain-containing leucine-rich transmembrane protein 3, and FLRT3, is a single-pass type I membrane protein which belongs to the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT3 contains one fibronectin type-III domain and ten LRR (leucine-rich) repeats and is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. It has a provocative expression pattern during somite development being expressed in regions of the somite where muscle precursor cells migrate from the dermomyotome and move into the myotome, and later in myotomal precursors destined to migrate towards their final destination. FLRT1, FLRT2 and FLRT3 are members of the FLRT family. The FLRT family of leucine-rich repeat (LRR) proteins is implicated in fibroblast growth factor (FGF) signalling, early embryonic development and neurite outgrowth. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. Two alternatively spliced transcript variants encoding the same protein have been described. The expression of FLRT3 is controlled by fibroblast growth factors (FGFs). FLRT3 has been implicated in neurite outgrowth after nerve damage, as a positive regulator of FGF signalling and in homotypic cell adhesion. FLRT3 may have a crucial role in regulating cellular adhesion between the epithelial apical ridge and the underlying mesenchyme and in establishing the dorso-ventral position of the ridge.

FLRT3 Related Studies

1. Smith TG, et al. (2006) The expression of Flrt3 during chick limb development. Int J Dev Biol. 50(8): 701-4.
2. Haines BP, et al. (2006) Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 297(1): 14-25.
3. Karaulanov EE, et al. (2006) A role for fibronectin-leucine-rich transmembrane cell-surface proteins in homotypic cell adhesion. EMBO Rep. 7(3): 283-90.
4. Gong SG, et al. (2009) Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development. Gene Expr Patterns. 29(7): 497-502.