FLRT2 Protein & Antibody

Fibronectin Leucine Rich Transmembrane protein 2

FLRT2 Products

FLRT2 Protein, Recombinant

Molecule	Species	Description	Cat. No
FLRT2	Human	FLRT2 Protein, Recombinant	11296-H08H

FLRT2 Antibody

Molecule	Application	Description	Cat. No
Human FLRT2	WB,Elisa	Mouse Monoclonal Antibody	11296-MM07

FLRT2 cDNA Clone

Molecule	Species	Description	Cat. No
FLRT2	Human	FLRT2 cDNA Clone / ORF Clone	HG11296-M
FLRT2	Mouse	FLRT2 cDNA Clone / ORF Clone	MG51074-G

FLRT2 Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>FLRT2

FLRT2 Alternative Names

FLRT2, UNQ232/PRO265, KIAA0405 [Homo sapiens]

Flrt2, KIAA0405 [Mus musculus]

FLRT2 Background

Fibronectin Leucine-Rich Transmembrane (FLRT) proteins are glycosylated membrane proteins expressed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the focal adhesion marker vinculin. FLRT1, FLRT2, and FLRT3, the three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT family members may function in cell adhesion and/or receptor signalling. Each member of the FLRT family has a distinct, highly regulated expression pattern, as was seen for the NLRR family. FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome, suggesting that interaction with FGF signalling may be a general property of FLRT proteins. All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. FLRT proteins have a dual role, promoting FGF signalling and modulating homotypic cell adhesion. FLRT2 played critical roles in craniofacial development, and it was also present in the vomero-nasal organ, mandibular primodia, and the posterior aspects of the unfused and fused secondary palatal shelves.

FLRT2 Related Studies

1. Lacy SE, et al. (1999) Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. Genomics. 62(3): 417-26.
2. Haines BP, et al. (2006) Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 297(1): 14-25.
3. Karaulanov EE, et al. (2006) A role for fibronectin-leucine-rich transmembrane cell-surface proteins in homotypic cell adhesion. EMBO Rep. 7(3): 283-90.
4. Maretto S, et al. (2008) Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 318(1): 184-93.
5. Gong SG, et al. (2009) Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development. Gene Expr Patterns. 9(7): 497-502.