FLRT1 Protein & Antibody

Fibronectin Leucine Rich Transmembrane protein 1

FLRT1 Products

FLRT1 Protein, Recombinant

Molecule	Species	Description	Cat. No
FLRT1	Human	FLRT1 Protein, Recombinant	11389-H08H

FLRT1 Antibody

Molecule	Application	Description	Cat. No
Human FLRT1	WB,Elisa	Mouse Monoclonal Antibody	11389-MM07
Human FLRT1	WB,Elisa	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11389-RP02

FLRT1 cDNA Clone

Molecule	Species	Description	Cat. No
FLRT1	Human	Homo sapiens FLRT1 cDNA Clone	HG11389-M

FLRT1 Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>FLRT1

FLRT1 Alternative Names

FLRT1, UNQ752/PRO1483, MGC21624 [Homo sapiens]

Flrt1, AW742165, D630040I23Rik [Mus musculus]

FLRT1 Background

The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicate a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR. This is consistent with an 'in vivo' role for FLRT1 regulation of FGF signalling via SFKs. Furthermore, the phosphorylation-dependent futile cycle mechanism controlling FGFR1 signalling is concurrently crucial for regulation of FLRT1-mediated neurite outgrowth. FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1.

FLRT1 Related Studies

1. Lacy SE, et al. (1999) Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. Genomics. 62(3): 417-26.
2. Haines BP, et al. (2006) Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 297(1): 14-25.
3. Maretto S, et al. (2008) Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 318(1): 184-93.
4. Wheldon LM, et al. (2010) Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling. PLoS One. 5(4): e10264.