+86-400-890-9989
Product Catalog
> FLRG Protein & Antibody (FSTL3) FLRG Protein & Antibody (FSTL3)
Follistatin-Like 3
FLRG Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| FLRG/Fstl3 | Mouse | FLRG/FSTL3 Protein, Recombinant | 10591-M08H |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Mouse FLRG/Fstl3 |
WB, ELISA | Rabbit Polyclonal Antibody | 10591-RP01 |
| Mouse FLRG/Fstl3 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10591-RP02 |
| Mouse FLRG/Fstl3 |
WB, ELISA | Rabbit Monoclonal Antibody | 10591-R131 |
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| FLRG/Fstl3 | Mouse | Mus musculus Fstl3/FLRG cDNA Clone | MG50029-M |
FLRG Alternative Names
FLRG, FSTL3, FSRP [Homo sapiens]
Flrg, Fstl3, E030038F23Rik, [Mus musculus]
FLRG Related Areas
Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>FLRG/FSTL3
Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>BMP Family>>FLRG/FSTL3
Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>> TGF-beta Superfamily Modulators>>FLRG/FSTL3
FLRG Related Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| Inhibin beta A/INHBA | Human | Inhibin beta A/INHBA Protein, Recombinant |
| Inhibin beta B/INHBB | Human | Inhibin beta B/INHBB Protein, Recombinant |
| ALK-2/ACVR1 | Human | ALK-2/ACVR1/Fc Protein, Recombinant |
| ALK-2/ACVR1 | Mouse | ALK-2/ACVR1/Fc Protein, Recombinant |
| ACVR2A | Human | ACVR2A/Fc Protein, Recombinant |
| ACVR2B | Human | ACVR2B/Fc Protein, Recombinant |
| ACVR2B | Human | ACVR2B Protein, Recombinant |
| ACVR2B | Human | ACVR2B/Fc Protein, Recombinant |
| ACVR2B | Mouse | ACVR2B Protein, Recombinant |
| FSTL1/Follistatin Like 1 | Human | FSTL1 Protein, Recombinant |
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| Inhibin alpha/INHA | Human | Homo sapiens Inhibin alpha/INHA cDNA Clone(NM_002191.2) |
| Inhibin beta A/INHBA | Human | Homo sapiens Inhibin beta A/INHBA cDNA Clone(NM_002192.2) |
| Inhibin beta B/INHBB | Human | Homo sapiens Inhibin beta B/INHBB cDNA Clone(NM_002193.2) |
| Inhibin beta C/INHBC | Human | Homo sapiens Inhibin beta C/INHBC cDNA Clone(NM_005538.2) |
| Inhibin beta E/INHBE | Human | Homo sapiens Inhibin beta E/INHBE cDNA Clone(NM_031479.3) |
| ALK-2/ACVR1 | Human | Homo sapiens ALK-2/ACVR1 transcript variant 2 cDNA Clone(NM_001111067.2) |
| ALK-4/ACVR1B | Human | Homo sapiens ALK-4/ACVR1B cDNA Clone(NM_004302.3) |
| ACVR2A | Human | Homo sapiens ACVR2A cDNA Clone(NM_001616.3) |
| ACVR2B | Human | Homo sapiens ACVR2B cDNA Clone(NM_001106.3) |
| Follistatin | Human | Homo sapiens Follistatin cDNA Clone(NM_013409.1) |
| FSTL1/Follistatin Like 1 | Human | Homo sapiens FSTL1 cDNA Clone(NM_007085.4) |
FLRG Background
Follistatin-like 3 (FLRG/Fstl3) is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. FLRG/Fstl3 is a recently described member of the FST family having an overall structure and activity profile similar to that of FST, including binding and neutralization of activin. FLRG/Fstl3 is expressed in a wide range of adult tissues, not detected in hematopoietic cells except in patients with a B cell chronic leukemia and a translocation. Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 of FLRG/Fstl3 or the nuclear form of FLRG/Fstl3 is probably involved in transcriptional regulation via interaction with MLLT10. Modulation of activin and other TGFβ superfamily signaling is the primary mechanism of action for both follistatin (FS) and FS-like 3 (FSTL-3). FLRG/Fstl3 is likely to be a local regulator of activin action in gonadal development and gametogenesis and, further, that activin appears to have important actions in gonadal development and function that are critical for normal reproduction.
FLRG Related Studies
- Sidis Y, et al. (2006) Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins. Endocrinology. 147(7): 3586-97.
- Schneyer A, et al. (2003) Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). Endocrinology. 144(5): 1671-4.
- Xia Y, et al. (2004) Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice. Mol Endocrinol. 18(4): 979-94.
