Gene Summary: The protein encoded by this FKBP3 gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. FKBP3 has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]General information above from NCBI
Enzyme regulation: Inhibited preferentially by rapamycin over FK506.
Subunit structure: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer.
Domain: The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C- terminus.
Subcellular location: Nucleus.
Tissue specificity: Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.
Sequence similarity: Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain.