FKBP12 Protein & Antibody (FKBP1A)

FK506-Binding Protein 12 (FK506 Binding Protein 1A, 12kDa)

FKBP12 Products

FKBP12 Protein, Recombinant

Molecule	Species	Description	Cat. No
FKBP12/FKBP1A	Human	FKBP12 Protein, Recombinant	10268-H08E
FKBP12/FKBP1A	Mouse	FKBP12 Protein, Recombinant	50265-M07E

FKBP12 Antibody

Molecule	Application	Description	Cat. No
Human FKBP12/FKBP1A	WB, ELISA	FKBP12/FKBP1A Antibody, Mouse MAb	10268-MM02
Human FKBP12/FKBP1A	WB, ELISA	FKBP12/FKBP1A Antibody, Rabbit PAb	10268-RP01
Human FKBP12/FKBP1A	WB, ELISA	FKBP12/FKBP1A Antibody, Rabbit PAb (Antigen Affinity Purified)	10268-RP02

FKBP12 cDNA Clone

Molecule	Species	Description	Cat. No
FKBP12/FKBP1A	Human	Homo sapiens FKBP12 transcript variant 12B cDNA Clone(NM_000801.3)	HG10268-M
FKBP12/FKBP1A	Mouse	Mus musculus FKBP12/FKBP1A cDNA Clone	MG50265-M

FKBP12 Related Areas

Enzyme>>Phosphatase & Regulator>>FKBP12/FKBP1A

Signal Transduction>>Phosphatase & Regulator>>FKBP12/FKBP1A

FKBP12 Alternative Names

FKBP12, FKBP1A, FKBP-12, FKBP1, FKBP12C, RP11-314N13.2, PKC12, PKCI2, PPIASE [Homo sapiens]

FKBP12, Fkbp1a, FKBP12-T1, FKBP12-T2, Fkbp, Fkbp1, mFKBP1, mFKBP12, RP23-419G21.5, 12kDa [Mus musculus]

FKBP12 Background

FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As a conserved molecules in many eukaryotes, FKBP12 has been characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues, and is involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP12 has attracted immense attention and its role in mediating the immunosuppressive functions. FKBP12 serves a dual role as a peptidyl-prolyl cis-trans isomerase and as a modulator of several cell signaling pathways. In one such a role, FKBP12 interacts with and regulates the functional state of the ryanodine Ca2+ channel receptor by altering protein conformation and coordinating multi-protein complex formation. Another physiological role of FKBP12 is an interactor and a regulator of the type I serine/threonine kinase receptors of TGF-beta superfamily. Current data, derived from detailed biochemical studies as well as from functional studies in various systems, suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular "gradient reader" for TGF-beta family morphogens. This aspect of FKBP12 function may be critical for cellular responsiveness to morphogenetic gradients of the TGF-beta family members during early development, serving to assure the translation of different ligand concentrations into different signaling readouts. In addition, FKBP12 may be involved in neuronal or astrocytic cytoskeletal organization and in the abnormal metabolism of tau protein in Alzheimer's disease (AD) damaged neurons.

FKBP12 Related Studies

1. Wang T, et al. (2004) The immunophilin FKBP12: a molecular guardian of the TGF-beta family type I receptors. Front Biosci. 9: 619-31.
2. Sugata H, et al. (2009) A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles. Neurosci Lett. 459(2): 96-9.
3. Brath U, et al. (2009) Differential responses of the backbone and side-chain conformational dynamics in FKBP12 upon binding the transition-state analog FK506: implications for transition-state stabilization and target protein recognition. J Mol Biol. 387(1): 233-44.
4. Scaramello CB, et al.. (2009) FKBP12 depletion leads to loss of sarcoplasmic reticulum Ca(2+) stores in rat vas deferens. J Pharmacol Sci. 109(2): 185-92.