FGFRL1 / FGFR5 Protein & Antibody

Fibroblast Growth Factor Receptor-Like 1 / Fibroblast Growth Factor Receptor 5

FGFRL1 / FGFR5 Products

FGFRL1 / FGFR5 Protein, Recombinant

Molecule	Species	Description	Cat. No
FGFRL1/FGFR5	Mouse	FGFRL1/FGFR5 Protein, Recombinant	50182-M08H

  50182-M08H:

1. Immobilized mouse at 10 µg/ml (100 µl/well) can bind mouse FGFR5. The EC₅₀ of mouse FGFR5 is 0.34 µg/mL. Measured by its binding ability in a functional ELISA.

2. Immobilized human FGF1 at 10µg/ml (100 µl/well) can bind mouse FGFR5 with a linear range of 0.08-2 µg/ml. Measured by its binding ability in a functional ELISA.

3. Immobilized human bFGF at 5 µg/ml (100 µl/well) can bind mouse FGFR5. The EC₅₀ of mouse FGFR5 is 0.22 µg/mL. Measured by its binding ability in a functional ELISA.

FGFRL1 / FGFR5 Antibody

Molecule	Application	Description	Cat. No
Mouse FGFRL1/FGFR5	WB, ELISA	Rabbit Polyclonal Antibody	50182-RP01
Mouse FGFRL1/FGFR5	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50182-RP02

FGFRL1 / FGFR5 cDNA Clone

Molecule	Species	Description	Cat. No
FGFRL1/FGFR5	Mouse	Mus musculus FGFRL1/FGFR5 cDNA Clone	MG50182-M

FGFRL1 / FGFR5 Related Areas

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFRL1/FGFR5

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFRL1/FGFR5

FGFRL1 / FGFR5 Alternative Names

FGFRL1, FGFR5, FGFR-5, FHFR [Homo sapiens]

Fgfrl1, FGFR5, FGFR-5, FGFR5beta, FGFR5gamma [Mus musculus]

FGFRL1 / FGFR5 Background

Fibroblast growth factor receptor-like 1 (FGFRL1) also known as Fibroblast growth factor receptor 5 (FGFR5), is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A unique feature of FGFRL1/FGFR5 is that it does not contain an intracellular tyrosine kinase domain. Some muscle types, including the muscles of the tongue and the diaphragm, express FGFRL1/FGFR5 at relatively high level. In contrast, the heart and the skeletal muscles of the limbs, as well as many other organs (brain, lung, liver, kidney, gut) express Fgfrl1 only at basal level. It is conceivable that FGFRL1/FGFR5 interacts with other Fgfrs, which are expressed in cartilage and muscle, to modulate FGF signaling.

FGFRL1 / FGFR5Related Studies

1. Wiedemann M, et al. (2000) Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Genomics. 69(2): 275-9.
2. Trueb B, et al. (2006) Expression of FGFRL1, a novel fibroblast growth factor receptor, during embryonic development. Int J Mol Med. 17(4): 617-20.
3. Wiedemann M, et al. (2001) The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein. Biochim Biophys Acta. 1520(3): 247-50.
4. Trueb B, et al. (2003) Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. J Biol Chem. 278(36): 33857-65.