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Product Catalog
> FGFR4 Protein & Antibody (CD334) FGFR4 Protein & Antibody (CD334)
Fibroblast Growth Factor Receptor 4 (Cluster of Differentiation 334)
FGFR4 Products
FGFR4 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| FGFR4/CD334 | Human | FGFR4/CD334/Fc Protein, Recombinant |
10538-H02H |
| FGFR4/CD334 | Human | FGFR4/CD334/Fc Protien, Recombinant | 10538-H03H |
| FGFR4/CD334 | Human | FGFR4/CD334 Protien, Recombinant | 10538-H08H |
| FGFR4 | Mouse | FGFR4/CD334/Fc Protien, Recombinant |
50194-M03H |
| FGFR4 | Mouse | FGFR4/CD334 Protien, Recombinant |
50194-M08H |
| FGFR4 | Rat | FGFR4 / FGF Receptor 4 Protein, Recombinant | 80093-R02H |
| FGFR4 | Rat | FGFR4 / FGF Receptor 4 Protein, Recombinant | 80093-R08H |
FGFR4 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Mouse FGFR4 |
ELISA | Rabbit Polyclonal Antibody | 50194-RP01 |
| Mouse FGFR4 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 50194-RP02 |
| Human FGFR4 |
WB, ELISA | FGFR4 / CD334 Antibody (Antigen Affinity Purified) | 10538-RP02 |
FGFR4 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| FGFR4/CD334 | Human | Homo sapiens FGFR4/CD334 cDNA Clone(NM_002011.3) | HG10538-M |
| FGFR4 | Mouse | Mus musculus FGFR4 cDNA Clone | MG50194-M |
| FGFR4 | Rat | Rat FGFR4 cDNA Clone / ORF Clone | RG80093-G |
FGFR4 Alternative Names
FGFR4, CD334, JTK2, MGC20292, TKF [Homo sapiens]
Fgfr4, Fgfr-4 [Mus musculus]
FGFR4 Related Areas
Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR4/CD334
Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFR4/CD334
Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR4/CD334
Stem Cell>>Neural Stem Cell (NSC)>>Neural Stem Cell Markers>>FGFR4/CD334
Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>FGFR4/CD334
Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFR4/CD334
Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FGFR4/CD334
Immunology>>Cluster of Differentiation>>Other>>FGFR4/CD334
FGFR4 Background
Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
FGFR4 Related Studies
- Hart KC, et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene. 19(29): 3309-20.
- Xie MH, et al. (1999) FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine. 11(10): 729-35.
- Yu C, et al. (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem. 275(20): 15482-9.
