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FGFR4 Protein & Antibody (CD334)

Fibroblast Growth Factor Receptor 4 (Cluster of Differentiation 334)

FGFR4 Products

FGFR4 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
FGFR4/CD334 Human FGFR4/CD334/Fc Protein, Recombinant 10538-H02H
FGFR4/CD334 Human FGFR4/CD334/Fc Protien, Recombinant 10538-H03H
FGFR4/CD334 Human FGFR4/CD334 Protien, Recombinant 10538-H08H
FGFR4 Mouse FGFR4/CD334/Fc Protien, Recombinant 50194-M03H
FGFR4 Mouse FGFR4/CD334 Protien, Recombinant 50194-M08H
FGFR4 Rat FGFR4 / FGF Receptor 4 Protein, Recombinant 80093-R02H
FGFR4 Rat FGFR4 / FGF Receptor 4 Protein, Recombinant 80093-R08H
FGFR4 Cynomolgus FGFR4 / FGF Receptor 4 Protein, Recombinant 90134-C02H

  10538-H02H:  ED50 = 2 - 6 ng / mlMeasured by its ability to inhibit FGF-acidic ( aFGF / FGF1 ) dependent proliferation of BALB/c 3T3 mouse fibroblasts.

  50194-M03H:  ED50 = 42.8 ng / mlMeasured by its ability to inhibit FGF-acidic ( aFGF / FGF1 ) dependent proliferation of BALB/c 3T3 mouse fibroblasts.

  50194-M08H:  ED50 =  75.6 ng / mlMeasured by its ability to inhibit FGF-acidic ( aFGF / FGF1 ) dependent proliferation of BALB/c 3T3 mouse fibroblasts.

FGFR4 Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
FGFR4
WB, ELISA FGFR4 / CD334 Antibody (Antigen Affinity Purified) 10538-RP02
Human
FGFR4
WB, ELISA FGFR4 / CD334 Antibody 10538-MM01
Mouse
FGFR4
ELISA Rabbit Polyclonal Antibody 50194-RP01
Mouse
FGFR4
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 50194-RP02

FGFR4 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
FGFR4/CD334 Human Homo sapiens FGFR4/CD334 cDNA Clone(NM_002011.3) HG10538-M
FGFR4 Mouse Mus musculus FGFR4 cDNA Clone MG50194-M
FGFR4 Rat Rat FGFR4 cDNA Clone / ORF Clone RG80093-G
FGFR4 Rat Rat FGFR4 ORF Expression Clone, untagged RG80093-G-N

FGFR4 Alternative Names

FGFR4, CD334, JTK2, MGC20292, TKF [Homo sapiens]

Fgfr4, Fgfr-4 [Mus musculus]

FGFR4 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR4/CD334

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFR4/CD334

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR4/CD334

Stem Cell>>Neural Stem Cell (NSC)>>Neural Stem Cell Markers>>FGFR4/CD334

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>FGFR4/CD334

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFR4/CD334

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FGFR4/CD334

Immunology>>Cluster of Differentiation>>Other>>FGFR4/CD334

FGFR4 Background

Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

FGFR4 Related Studies

  1. Hart KC, et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene. 19(29): 3309-20.
  2. Xie MH, et al. (1999) FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine. 11(10): 729-35.
  3. Yu C, et al. (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem. 275(20): 15482-9.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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