Anti-FGFR4 Antibody

Cat: 50194-RP01
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Anti-FGFR4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-FGFR4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse FGFR4
Immunogen
Human cell-derived rM FGFR4 extracellular domain (Catalog#50194-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse FGFR4 / FGF Receptor 4 extracellular domain (rM FGFR4; Catalog#50194-M08H; Met 1-Asp 366; NP_032037.2). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FGFR4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-FGFR4 Antibody Alternative Names
Anti-Fgfr-4 Antibody
FGFR4 Background Information

Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
fibroblast growth factor receptor 4
References
  • Hart KC, et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene. 19(29): 3309-20.
  • Xie MH, et al. (1999) FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine. 11(10): 729-35.
  • Yu C, et al. (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem. 275(20): 15482-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-FGFR4 Antibody Rabbit Polyclonal ELISA 90134-T16
    Anti-FGFR4 Antibody Rabbit Monoclonal ELISA 90134-R148
    Anti-FGFR4 Antibody Rabbit Polyclonal ELISA 90134-RP01
    Anti-FGFR4 Antibody Rabbit Monoclonal ELISA(Cap) 80093-R124
    Anti-FGFR4 Antibody Rabbit Polyclonal ELISA,IHC-P 80093-RP02
    Anti-FGFR4 Antibody Rabbit Polyclonal ELISA 50194-T16
    Anti-FGFR4 Antibody Rabbit Polyclonal ELISA 50194-RP02
    Anti-FGFR4 Antibody Rabbit Polyclonal ELISA,IHC-P 10538-RP02
    Anti-FGFR4 Antibody Rabbit Polyclonal ELISA 10538-T16
    Anti-FGFR4 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10538-MM01
    Anti-FGFR4 Antibody Rabbit Monoclonal ELISA 10538-R249
    Anti-FGFR4 Antibody Rabbit Polyclonal ELISA 10538-RP01
    Anti-FGFR4 Antibody Rabbit Polyclonal WB,ELISA 10538-T48
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