FGFR4 / FGF Receptor 4 Antibody

Fibroblast Growth Factor Receptor 4 ( FGFR4 ) Antibody

FGFR4 Antibody Product Information

• Immunogen: Human cell-derived rM FGFR4 extracellular domain ( Catalog # 50194-M08H )
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: Produced in rabbits immunized with purified, human cell-derived, recombinant mouse FGFR4 / FGF Receptor 4 extracellular domain ( rM FGFR4; Catalog#50194-M08H; Met 1- Asp 366; NP_032037.2 ). Total IgG was purified by Protein A affinity chromatography.

FGFR4 Antibody Usage Guide

• Specificity: Mouse FGFR4
• Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse FGFR4 in WB.
• Direct ELISA: This antibody can be used at 0.5-1μg/mL with the appropriate secondary reagents to detect mouse FGFR4. The detection limit for mouse FGFR4 is approximately 0.00975 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for 1 month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

FGFR4 Antibody Related Products &Topics

Related Areas:

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR4/CD334

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFR4/CD334

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR4/CD334

Stem Cell>>Neural Stem Cell (NSC)>>Neural Stem Cell Markers>>FGFR4/CD334

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>FGFR4/CD334

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFR4/CD334

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FGFR4/CD334

Immunology>>Cluster of Differentiation>>Other>>FGFR4/CD334

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
FGFR4/CD334	Human	FGFR4/CD334/Fc Protein, Recombinant	10538-H02H
FGFR4/CD334	Human	FGFR4/CD334/Fc Protien, Recombinant	10538-H03H
FGFR4/CD334	Human	FGFR4/CD334 Protien, Recombinant	10538-H08H
FGFR4	Mouse	FGFR4/CD334/Fc Protien, Recombinant	50194-M03H
FGFR4	Mouse	FGFR4/CD334 Protien, Recombinant	50194-M08H
FGFR4	Rat	FGFR4 / FGF Receptor 4 Protein, Recombinant	80093-R02H
FGFR4	Rat	FGFR4 / FGF Receptor 4 Protein, Recombinant	80093-R08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse FGFR4	ELISA	Rabbit Polyclonal Antibody	50194-RP01
Mouse FGFR4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50194-RP02
Human FGFR4	WB, ELISA	FGFR4 / CD334 Antibody (Antigen Affinity Purified)	10538-RP02

FGFR4 Antibody Background

Fibroblast growth factors (FGFs) and their receptors (FGFRs) influence a variety of physiological and pathological cellular processes, and different ligand/receptor pairs regulate cell growth in either a positive or negative manner depending on the cell type and stage of development. At least 22 distinct FGF ligands and 4 receptors (FGFR1–4) have been identified to date. Mouse FGFR4, also designated as protein-tyrosine kinase receptor MPK-11, is a member of FGFR subfamily of the tyrosine protein kinase superfamily. Mouse FGFR4 is originally isolated from fetal cerebellar RNA, and this type I  transmembrane glycoprotein contains 3 C2-type I g-like domains in the extracellular domain and a cytoplasmic tyrosine-kinase domain. The putative ligand for mouse FGFR4 is basic fibroblast growth factor, FGF6 and FGF19. Studies in FGFR4 null mice indicated that FGFR4 may be required for the development of skeletal muscle cell lineages, as well as effective muscle regeneration, and furthermore, it is also involved in cholesterol and bile acid metabolism and homeostasis.

References

1. Stark, KL. et al., 1991, Development. 113: 641-51.
2. Huang, X. et al., 2007, Diabetes. 56: 2501-10.
3. Po, Zhao. et al., 2006, J. Biol. Chem. 281: 429-38.
4. Holt, JA. et al., 2003, Genes&Dev. 17: 1581-91.