All FGFR3 reagents are produced in house and quality controlled, including 8 FGFR3 Antibody, 1 FGFR3 ELISA, 13 FGFR3 Gene, 8 FGFR3 Lysate, 8 FGFR3 Protein, 1 FGFR3 qPCR. All FGFR3 reagents are ready to use.
Recombinant FGFR3 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His, C-human IgG1-Fc & His.
FGFR3antibodies are validated with different applications, which are ELISA(Cap), ELISA, IHC-P, ELISA(Det), WB.
FGFR3cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each FGFR3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
FGFR3ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.