FGFR3 Protein (CD333 Protein)

Fibroblast Growth Factor Receptor 3 (Cluster of Differentiation 333)

FGFR3 Products

FGFR3 Protein, Recombinant

Molecule	Species	Description	Cat. No
FGFR3	Mouse	FGFR3/Fc Protein, Recombinant	50071-M03H
FGFR3	Mouse	FGFR3 Protein, Recombinant	50071-M08H

  50071-M03H:  Measured by its ability to bind mouse aFGF in a functional ELISA.

  50071-M08H:  The ED₅₀ for this effect is typically 300 ng/mL. Measured by its ability to inhibit FGF acidic dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts.

FGFR3 cDNA Clone Products

Molecule	Species	Description	Cat. No
FGFR3	Mouse	Mus musculus FGFR3 cDNA Clone	MG50071-M

FGFR3 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR3/CD333

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFR3/CD333

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR3/CD333

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>FGFR3/CD333

Cancer>>Cancer Biomarkers>>FGFR3/CD333

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFR3/CD333

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FGFR3/CD333

Immunology>>Cluster of Differentiation>>Other>>FGFR3/CD333

FGFR3 Alternative Names

FGFR3, CD333, ACH, CEK2, HSFGFR3EX, JTK4 [Homo sapiens]

Fgfr3, Fgfr-3, HBGFR [Mus musculus]

FGFR3 Background

FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.

FGFR3 Related Studies

1. Keegan K, et al. (1991) Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc Natl Acad Sci. 88(4):1095-9.
2. Hafner C, et al. (2007) FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin. J Invest Dermatol. 127(7):1572-3.
3. Lamy A, et al. (2006) Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations. J Urol. 176(6 Pt 1):2686-9.
4. Schweitzer DN, et al. (2001) Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu substitution in FGFR3. Am J Med Genet. 98 (1):75-91.