FGFR2 Protein & Antibody (CD332)

Fibroblast Growth Factor Receptor 2 (Cluster of Differentiation 332)

FGFR2 Products

FGFR2 Protein, Recombinant

Molecule	Species	Description	Cat. No
FGFR2/CD332	Human	FGFR2 / CD332 / Fc Protein, Recombinant	10824-H03H
FGFR2/CD332	Human	FGFR2 / CD332 Protein, Recombinant	10824-H08H
FGFR2/CD332	Human	FGFR2 / CD332 (aa 400-821) Protein, Recombinant, with GST Tag	10824-H20B1

  10824-H03H : The ED₅₀ for this effect is typically 0.5-2.5 ng/ml. Measured by its ability to inhibit FGF-acidic (aFGF/FGF1) dependent proliferation of BALB/3T3 mouse fibroblasts.

  10824-H08H : The ED₅₀ for this effect is typically 200-400 ng/ml. Measured by its ability to inhibit FGF acidic dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts.

FGFR2 Antibody

Molecule	Application	Description	Cat. No
Human FGFR2/CD332	WB, ELISA	FGFR2 / CD332 Antibody, Rabbit MAb	10824-R106
Human FGFR2/CD332	WB, ELISA	FGFR2 / CD332 Rabbit PAb	10824-RP01
Human FGFR2/CD332	WB, ELISA	FGFR2 / CD332 Rabbit PAb (Antigen Affinity Purified)	10824-RP02

FGFR2 cDNA Clone

Molecule	Species	Description	Cat. No
FGFR2/CD332	Human	Homo sapiens FGFR2 / CD332 cDNA Clone	HG10824-M

FGFR2 Alternative Names

FGFR2, CD332, KGFR, ECT1, CFD1, CEK3, BEK, BFR-1, FLJ98662, JWS, K-SAM, TK14, TK25 [Homo sapiens]

Fgfr2, Fgfr-2, AU043015, AW556123, Bek, Fgfr-7, Fgfr7, KGFRTr, MGC102519, svs [Mus musculus]

FGFR2 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR2/CD332

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFR2/CD332

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR2/CD332

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>FGFR2/CD332

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFR2/CD332

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FGFR2/CD332

Immunology>>Cluster of Differentiation>>Other>>FGFR2/CD332

FGFR2/CD332 Background

FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.

FGFR2/CD332 Related Studies

1. Marie PJ, et al. (2003) Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. Histol. 17(3):877-85.
2. Park WJ, et al. (1996) Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability. Hum Mol Genet. 4(7):1229-33.
3. Orr-Urtreger A, et al. (1993) Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol. 158(2):475-86.