FGFR1 Protein & Antibody (CD331 Protein)

Fibroblast Growth Factor Receptor 1 (Cluster of Differentiation 331)

FGFR1 Products

FGFR1 Protein, Recombinant

Molecule	Species	Description	Cat. No
FGFR1/CD331	Human	FGFR1/CD331/Fc Protein, Recombinant	10616-H03H
FGFR1/CD331	Human	FGFR1/CD331 Protein, Recombinant	10616-H08H
FGFR1/CD331	Human	FGFR1 / CD331 Protein, Recombinant, with GST Tag	10616-H20B1
FGFR1	Mosue	FGFR1/Fc Protein, Recombinant	50186-M02H
FGFR1	Mosue	FGFR1 Protein, Recombinant	50186-M08H

  10616-H03H: ED₅₀ = 2-4 ng / ml. Measured by its ability to inhibit FGF-acidic (aFGF / FGF1) dependent proliferation of BALB/c 3T3  mouse fibroblasts.

  10616-H08H: The ED₅₀ for this effect is typically 26.7 ng/ml. Measured by its ability to inhibit aFGF / FGF-acidic dependent proliferation of BALB / 3T3 mouse fibroblasts.

  50186-M02H: The ED₅₀ for this effect is typically 1.57 ng/mL. Measured by its ability to inhibit FGF acidic (aFGF / FGF1) dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts.

  50186-M08H: The ED₅₀ for this effect is typically 189 ng/mL. Measured by its ability to inhibit FGF acidic (aFGF/FGF1) dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts.

FGFR1 Antibody

Molecule	Application	Description	Cat. No
Mouse FGFR1/CD331	WB, ELISA	FGFR1 / CD331 Antibody	50186-RP01
Mouse FGFR1/CD331	WB, ELISA	FGFR1 / CD331 Antibody (Antigen Affinity Purified)	50186-RP02

FGFR1 cDNA Clone

Molecule	Species	Description	Cat. No
FGFR1/CD331	Human	Homo sapiens FGFR1/CD331 cDNA Clone	HG10616-M
FGFR1/CD331	Mouse	Mus musculus FGFR1 cDNA Clone	MG50186-M
FGFR1/CD331	Cynomolgus	FGFR1 cDNA Clone / ORF Clone	KG90075-G

FGFR1 Alternative Names

FGFR1, CD331, FLT2, KAL2, BFGFR, CEK, FGFBR, FLG, FLJ99988, HBGFR, N-SAM, OGD [Homo sapiens]

Fgfr1, Flt-2, AW208770, FLG, Fgfr-1 [Mus musculus]

FGFR1 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR1/CD331

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFR1/CD331

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR1/CD331

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>FGFR1/CD331

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFR1/CD331

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FGFR1/CD331

Immunology>>Cluster of Differentiation>>Other>>FGFR1/CD331

FGFR1/CD331 Background

FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ，idiopathic hypogonadotropic hypogonadism， Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.

FGFR1/CD331 Related Studies

1. Schlessinger J, et al. (2000) Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 6(3):743-50.
2. Dodé C, et al. (2007) Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis. Hum Mutat. 28(1): 97-8.
3. Kim HG, et al. (2005) Hypogonadotropic hypogonadism and cleft lip and palate caused by a balanced translocation producing haploinsufficiency for FGFR1. J Med Genet. 42(8):666-72.