FGFBP3

FGFBP3 is a member of the fibroblast growth factor-binding protein family. Members of this family binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis. Fibroblast growth factors (FGFs) are important regulators of cell migration, proliferation and differentiation, e.g., during embryogenesis and wound healing, and under several pathological conditions including tumor growth and tumor angiogenesis. Expression of FGF-BP increases after injury to murine and human skin, in particular in keratinocytes. This upregulation is most likely achieved by major keratinocyte mitogens present at the wound site. FGFBP3 is a positive regulator of fibroblast growth factor receptor signaling pathway and vascular permeability. It interacts with 2,3,7,8-tetrachlorodibenzodioxine, benzopyrene and valproic acid. FGFBP3 also exhibits fibroblast growth factor binding (orthology) and heparin binding (orthology).

FGFBP3 Related Areas

Cancer>>Growth Factor & Receptor>>FGFBP3

FGFBP3 Alternative Names

PSEC0101, C10orf13, FGF-BP3, MGC39320, FGF-binding protein 3, FGFBP-3, fibroblast growth factor-binding protein 3 [Homo sapiens]

2610306H15Rik, Fgf-bp3, FGF-binding protein 3, FGFBP-3, fibroblast growth factor-binding protein 3 [Mus musculus]

Human FGFBP3 Protein General Information

 

• Protein names: Fibroblast growth factor-binding protein 3, Short name=FGFBP3
• Sequence length: 258 AA.
• Sequence similarities: FGFBP3 belongs to the fibroblast growth factor-binding protein family.
• Subunit structure: FGFBP3 interacts with FGF1.
• Subcellular location: Secreted

General information above from UniProt