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FGF21  Gene / cDNA Clone

All FGF21 Reagents

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FGF21 Related Area

FGF21 Related Pathways

    FGF21 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    FGF21 Summary & Protein Information

    FGF21 Background

    Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
    General information above from NCBI
    Subunit structure: Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4. {ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:18829467, ECO:0000269|PubMed:19117008}.
    Subcellular location: Secreted {ECO:0000305}.
    Sequence similarity: Belongs to the heparin-binding growth factors family. {ECO:0000305}.
    General information above from UniProt

    Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

    FGF21 Alternative Name

    FGF21,Fibroblast Growth Factor 21, [Cynomolgus]
    FGF21,FGF-21,UNQ3115/PRO10196, [human]
    Fgf21,FGF-21, [mouse]

    FGF21 Related Studies

  • Zhang X, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53.
  • Lundåsen T, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40.
  • Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"