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FGF18 Protein

Fibroblast Growth Factor 18

FGF18 Products

FGF18 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
FGF18 Mouse FGF18 Protein, Recombinant 50177-M08H
FGF18 Human FGF18 / FGF-18 Protein, Recombinant 13206-H08H

FGF18 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
FGF18 Human Human FGF18 cDNA Clone / ORF Clone HG13206-G
FGF18 Mouse Mus musculus FGF18 cDNA Clone MG50177-M
FGF18 Canine Canine FGF18 Gene cDNA Clone / ORF Clone DG70059-G

FGF18 Related Areas

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGF18

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGF18

FGF18 Alternative Names

FGF18, UNQ420/PRO856, FGF-18, ZFGF5 [Homo sapiens]

Fgf18, RP23-413O19.3, D130055P09Rik, FGF-18 [Mus musculus]

FGF18 Related Products

Protein Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
aFGF Human aFGF protein, Recombinant
aFGF Mouse aFGF protein, Recombinant
FGF2/bFGF Human bFGF Protein, Recombinant
FGF9 Human FGF9/Fc Protein, Recombinant
FGF10 Human FGF10 Protein, Recombinant
FGF21 Human FGF21 Protein, Recombinant
FGF21 Mouse FGF21 Protein, Recombinant
FGFR1 Human FGFR1 Protein, Recombinant
FGFR1 Human FGFR1/Fc Protein, Recombinant
FGFR2 Human FGFR2/CD332/Fc Protein, Recombinant
FGFR2 Human FGFR2/CD332 Protein, Recombinant
FGFR3 Mouse FGFR3/Fc Protein, Recombinant
FGFR4 Human FGFR4/Fc Protein, Recombinant
FGFR4 Human FGFR4/Fc Protein, Recombinant
FGFR4/CD334 Human FGFR4/CD334 Protien, Recombinant
FGFR4 Mouse FGFR4 Protein, Recombinant
FGFR4 Mouse FGFR4/Fc Protein, Recombinant
FGFRL1/FGFR5 Mouse FGFRL1/FGFR5 Protein, Recombinant

Antibody Products

Molecule Application Description //For Detailed Info. and Price------CLICK!
Human
aFGF
WB, ELISA Mouse Monoclonal Antibody
Human
aFGF
WB, ELISA Rabbit Polyclonal Antibody 
Human
aFGF
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse
aFGF
WB, ELISA Rabbit Polyclonal Antibody 
Human
bFGF/FGF2
WB, ELISA Rabbit Monoclonal Antibody
Human
bFGF/FGF2
ELISA Rabbit Polyclonal Antibody
Human
bFGF/FGF2
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human
FGFR2
WB, ELISA Rabbit Polyclonal Antibody
Human
FGFR2
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse
FGFR4
ELISA Rabbit Polyclonal Antibody
Mouse
FGFR4
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse
FGFRL1/FGFR5
WB, ELISA Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
FGF2/bFGF Human Homo sapiens bFGF cDNA Clone(NM_002006.4)
FGF5 Human Homo sapiens FGF5 transcript variant 1 cDNA Clone(NM_004464.3)
FGF7 Human Homo sapiens FGF7/KGF cDNA Clone (NM_002009.2)
FGF9 Human Homo sapiens FGF9 cDNA Clone(NM_002010.1)
FGF10 Human Homo sapiens FGF10 cDNA Clone(NM_004465.1)
FGF12 Human Homo sapiens FGF12 transcript variant 2 cDNA Clone(NM_004113.4)
FGF13 Human Homo sapiens FGF13 cDNA Clone(NM_004114.2)
FGF14 Human Homo sapiens FGF14 cDNA Clone(NM_004115.3)
FGF21 Human Homo sapiens FGF21 cDNA Clone(NM_019113.2)
FGFR1/CD331 Human Homo sapiens FGFR1/CD331 cDNA Clone
FGFR2/CD332 Human Homo sapiens FGFR2/CD332 cDNA Clone

FGF18 Background

Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that FGF18 is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Experiment datas identified FGF18 as a selective ligand for FGFR3 in limb bud mesenchymal cells, which suppressed proliferation and promoted their differentiation and production of cartilage matrix. FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis.

FGF18 Related Studies

  1. Ohbayashi N, et al. (2002) FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev. 16(7): 870-9.
  2. Davidson D, et al. (2005) Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol Chem. 280(21): 20509-15.
  3. Liu Z, et al. (2007) FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Dev Biol. 302(1): 80-91.