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FGF18 Protein, Antibody, ELISA Kit, cDNA Clone

Mouse FGF18 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
50177-M08H-20
50177-M08H-50
20 µg / $140
50 µg / $290
Add to Cart

Human FGF18 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
13206-H08H-20
13206-H08H-50
20 µg / $100
50 µg / $190
Add to Cart

FGF18 Related Areas

FGF18 Related Pathways

FGF18 Related Product

FGF18 Related Information

FGF18 Background

Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.
General information above from NCBI
Subunit structure: Interacts with FGFR3 and FGFR4.
Subcellular location: Secreted (By similarity).
Sequence similarities: Belongs to the heparin-binding growth factors family.C
General information above from UniProt

Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that FGF18 is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Experiment datas identified FGF18 as a selective ligand for FGFR3 in limb bud mesenchymal cells, which suppressed proliferation and promoted their differentiation and production of cartilage matrix. FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis.

FGF18 Altermative Names

FGF18 Related Studies

  • Ohbayashi N, et al. (2002) FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev. 16(7): 870-9.
  • Davidson D, et al. (2005) Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol Chem. 280(21): 20509-15.
  • Liu Z, et al. (2007) FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Dev Biol. 302(1): 80-91.
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