All FGF18 reagents are produced in house and quality controlled, including 2 FGF18 Antibody, 36 FGF18 Gene, 1 FGF18 IPKit, 2 FGF18 Lysate, 2 FGF18 Protein, 2 FGF18 qPCR. All FGF18 reagents are ready to use.
Recombinant FGF18 proteins are expressed by HEK293 Cells with fusion tags as C-His.
FGF18antibodies are validated with different applications, which are WB, ELISA, IP.
FGF18cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each FGF18 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that FGF18 is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Experiment datas identified FGF18 as a selective ligand for FGFR3 in limb bud mesenchymal cells, which suppressed proliferation and promoted their differentiation and production of cartilage matrix. FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis.