Anti-FGF14 Antibody

Cat: 13654-RP01
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Anti-FGF14 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-FGF14 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human FGF14
Immunogen
Recombinant Human FGF14 / SCA27 (isoform 1B) protein (Catalog#13654-HNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Human FGF14 / SCA27 (isoform 1B) (rh FGF14 / SCA27 (isoform 1B); Catalog#13654-HNAE; NP_787125.1; Lys64-Thr252). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-FGF14 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-FGF14 Antibody Alternative Names
Anti-FGF-14 Antibody;Anti-FHF-4 Antibody;Anti-FHF4 Antibody;Anti-SCA27 Antibody
FGF14 Background Information

FGF14 is a member of the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF14 is probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). It is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia. It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits.

Full Name
fibroblast growth factor 14
References
  • Wang Q, et al. (2002) Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. Neuron. 35 (1): 25-38.
  • Zhao Y, et al. (2007) Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor. Am J Med Genet. 144B (3): 395-6.
  • Lou JY, et al. (2005) Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels. J Physiol. 569 (1): 179-93.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-FGF14 Antibody Rabbit Monoclonal ELISA 13654-R107
    Anti-FGF14 Antibody Rabbit Polyclonal ELISA 13654-T16
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