FGF10 Protein (Native)

Fibroblast growth factor 10 Protein Datasheet

FGF10 Protein Product Information

• FGF10 Synonym: FGF10
• Protein Construction: A DNA sequence encoding the mature form of human FGF10 (NP_004456.1) (Gln 38- Ser 208) was expressed.
• Source: Human
• Expression Host: E.coli

FGF10 Protein QC Testing

• Purity: >98 % as determined by SDS-PAGE.
• Endotoxin: Please contact us for more information.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Met
• Molecular Mass: The recombinant human FGF10 consists of 172 amino acids and has a predicted molecular mass of 19.6 KDa as estimated in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile 20mM Tris, pH7.5
• SDS-PAGE:

FGF10 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted and be used as soon as possible.; Avoid repeated freeze-thaw cycles
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FGF10 Protein Description

The fibroblast growth factors (FGFs) are a growing family of heparin-binding growth factors that that regulate a variety of physiological processes in both developing and adult organism. The secreted human FGF10 exists most abundantly in the embyro and adult lung, and is most closely related to FGF7. It signaling through FGF receptor 2 (FGFR2) controls survival, proliferation, and differentiation of distal-alveolar epithelial progenitor cells during lung development. FGF10 overexpression during both the inflammatory and fibrotic phases results in a greatly reduced extent of lung fibrosis, suggesting that FGF10 may be useful as a novel approach to the treatment of pulmonary fibrosis. Additionally, FGF10 is also proposed as a growth factor active involved in the process of wound healing and limb bud formation. Human FGF10 shares approximately 92% and 95% amino acid sequence identity with mouse and rat FGF10, respectively.

References

1. Krejci P. et al., 2009, Hum Mutat. 30(9):1245-1255.
2. Abler L.L. et al., 2009, Dev Dyn. 238(8):1999-2013.
3. Gupte V.V. et al., 2009, Am J Respir Crit Care Med. 180(5):424-436.
4. Carraro G. et al., 2009, Dev Biol. 333(2):238-250.