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FCRL3  Protein, Antibody, ELISA Kit, cDNA Clone

FCRL3 Related Area

FCRL3 Related Pathways

    FCRL3 Summary & Protein Information

    FCRL3 Background

    Subunit structure: Interacts with PTPN6, PTPN11, SYK and ZAP70. {ECO:0000269|PubMed:12051764}.
    Subcellular location: Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.
    Tissue specificity: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level). {ECO:0000269|PubMed:11493702, ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:15838509, ECO:0000269|PubMed:16849395}.
    Post-translational: Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases. {ECO:0000269|PubMed:12051764}.
    Involvement in disease: DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269|PubMed:15838509, ECO:0000269|PubMed:16176992, ECO:0000269|PubMed:16476711, ECO:0000269|PubMed:16859508, ECO:0000269|PubMed:17133579, ECO:0000269|PubMed:17179172, ECO:0000269|PubMed:17763442}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; DISEASE: Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.
    Sequence similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    FCRL3 Alternative Name

    CD307c,FCRH3,IFGP3,IRTA3,SPAP2, []

    FCRL3 Related Studies

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